| Definition |
A diagnostic or phenotype definition for the disease |
no |
| NIHResearchPriorityAssignment |
NIH Highlighted Topics funding-priority assignment |
no |
| Stage |
|
no |
| AnimalModel |
|
no |
| ICIMDAssignment |
ICIMD category/group classification assignment for inherited metabolic disord... |
no |
| Diagnosis |
|
no |
| Dataset |
A reference to a publicly available omics or phenotype dataset |
no |
| IUISAssignment |
IUIS primary immunodeficiency classification assignment |
no |
| Discussion |
A thread-like record of an open question, controversy, curation todo, emergin... |
no |
| ExperimentalControl |
A comparator or control condition for an experiment, such as an isogenic wild... |
no |
| GeneCaseFraction |
A structured estimate of the fraction of cases of a genetically heterogeneous... |
no |
| ImagingFinding |
A finding detected by in-vivo medical imaging (MRI, CT, PET, ultrasound, etc |
no |
| CausalEdge |
A reference to a downstream effect or consequence in a causal relationship |
yes |
| Finding |
A key finding or claim extracted from a source (publication or dataset) |
no |
| DifferentiatingMechanism |
A mechanism or feature that distinguishes a grouping member from its siblings... |
no |
| ProgressionInfo |
|
no |
| EpidemiologyInfo |
|
no |
| Experiment |
A structured experiment or protocol-level study design that can be proposed t... |
yes |
| InfectiousAgent |
|
no |
| Pathophysiology |
|
no |
| Treatment |
|
no |
| ComorbidityHypothesis |
Mechanistic hypothesis for a comorbidity association, with rich text and embe... |
no |
| AssociationSignal |
An association signal from EHR, registry, or computational sources, optionall... |
no |
| Phenotype |
|
no |
| ModelingConsideration |
|
no |
| PhenotypeReadout |
Links an investigation-readout phenotype (an abnormal electrophysiology, func... |
yes |
| UpstreamConditionHypothesis |
Hypothesized upstream condition that may explain both A and B |
no |
| GroupingMember |
One member of a grouping, referenced by foreign key, together with the mechan... |
no |
| ReferenceRange |
A population reference interval for a clinical laboratory analyte |
yes |
| TreatmentMechanismTarget |
Links a treatment to a specific pathophysiology mechanism node it targets |
yes |
| ExperimentalPerturbation |
A structured perturbation, intervention, or exposure used in an experiment |
no |
| ClinicalBurden |
Disease-level assessment of the typical clinical burden imposed by a disease |
yes |
| AgentLifeCycleStage |
|
no |
| ICDOMorphologyAssignment |
ICD-O morphology classification assignment for neoplastic diseases |
no |
| Inheritance |
|
no |
| AlgorithmValidationStatus |
Validation maturity of a phenotype algorithm / computable case definition: a ... |
no |
| BiomarkerReadout |
Links a biochemical biomarker to a pathograph node that it measures, reflects... |
yes |
| ExternalAssertion |
An externally curated assertion or registry record relevant to a disease or v... |
no |
| SurrogateEndpoint |
A regulatory surrogate endpoint assertion curated from FDA's surrogate endpoi... |
no |
| Prevalence |
|
no |
| HistopathologyFinding |
A histopathologic finding from microscopic examination of tissue |
no |
| PhenotypeContext |
A context-specific annotation qualifying how a phenotype manifests under part... |
yes |
| Subtype |
|
no |
| Biochemical |
|
no |
| GroupingCriteria |
The shared membership criteria for a grouping, pairing a human-readable descr... |
no |
| AgentLifeCycle |
|
no |
| ModelMechanismLink |
Links an experimental model to a specific pathophysiology mechanism node, wit... |
yes |
| ExperimentalReadout |
A structured readout or outcome measured in an experiment |
no |
| Variant |
A genetic variant associated with a disease, including coding and non-coding ... |
no |
| ClinicalTrial |
A clinical trial relevant to treatment or research of a disease |
yes |
| AssociationStatistics |
Statistical summary with evidence for an association signal |
no |
| HarrisonsChapterAssignment |
Harrison's internal medicine chapter classification assignment |
no |
| LysosomalStorageAssignment |
Lysosomal storage disease biochemical classification assignment |
no |
| MechanisticNosologyAssignment |
Mechanistic/pathway-based disease classification assignment |
no |
| Transmission |
|
no |
| ChannelopathyAssignment |
Channelopathy organ system classification assignment |
no |
| ExperimentalModel |
A disease-relevant non-animal experimental model system |
no |
| DifferentialDiagnosis |
A disease or condition that presents similarly to the focal disease and must ... |
no |
| CriteriaSet |
A named criteria grouping within a definition |
no |
| ComputationalModel |
A computational or in-silico model relevant to understanding disease mechanis... |
no |
| MechanisticHypothesis |
Disease-level hypothesis metadata used to organize downstream causal edges in... |
no |
| Genetic |
|
no |
| Environmental |
An environmental factor, exposure, or context relevant to disease |
no |
| ClassificationAssignment |
Base class for classification assignments with evidence |
no |