Skip to content

Class: ClinicalBurden

Disease-level assessment of the typical clinical burden imposed by a disease. This captures the overall burden of the disease concept and is distinct from severity annotations on individual phenotypes.

URI: dismech:class/ClinicalBurden

 classDiagram
    class ClinicalBurden
    click ClinicalBurden href "../../classes/ClinicalBurden/"
      ClinicalBurden : burden_level





        ClinicalBurden --> "1" ClinicalBurdenLevelEnum : burden_level
        click ClinicalBurdenLevelEnum href "../../enums/ClinicalBurdenLevelEnum/"



      ClinicalBurden : evidence





        ClinicalBurden --> "* _recommended_" EvidenceItem : evidence
        click EvidenceItem href "../../classes/EvidenceItem/"



      ClinicalBurden : notes

      ClinicalBurden : rationale

Slots

Name Cardinality and Range Description Inheritance
burden_level 1
ClinicalBurdenLevelEnum		 Coarse disease-level clinical burden category direct
rationale 0..1 recommended
String		 Curator rationale for assigning this burden level, including what aspects of ... direct
evidence * recommended
EvidenceItem		 Evidence supporting the disease-level clinical burden assessment direct
notes 0..1
String		 direct

Usages

used by used in type used
Disease clinical_burden range ClinicalBurden

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type Mapped Value
self dismech:ClinicalBurden
native dismech:ClinicalBurden

LinkML Source

Direct

name: ClinicalBurden
description: Disease-level assessment of the typical clinical burden imposed by a
  disease. This captures the overall burden of the disease concept and is distinct
  from severity annotations on individual phenotypes.
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- burden_level
- rationale
- evidence
- notes
slot_usage:
  burden_level:
    name: burden_level
    required: true
  rationale:
    name: rationale
    description: Curator rationale for assigning this burden level, including what
      aspects of functional impact, morbidity, duration, management burden, or long-term
      consequence drive the assessment.
    recommended: true
  evidence:
    name: evidence
    description: Evidence supporting the disease-level clinical burden assessment.
      Prefer sources that describe typical course, functional impact, morbidity, mortality,
      or management burden.
    recommended: true

Induced

name: ClinicalBurden
description: Disease-level assessment of the typical clinical burden imposed by a
  disease. This captures the overall burden of the disease concept and is distinct
  from severity annotations on individual phenotypes.
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  burden_level:
    name: burden_level
    required: true
  rationale:
    name: rationale
    description: Curator rationale for assigning this burden level, including what
      aspects of functional impact, morbidity, duration, management burden, or long-term
      consequence drive the assessment.
    recommended: true
  evidence:
    name: evidence
    description: Evidence supporting the disease-level clinical burden assessment.
      Prefer sources that describe typical course, functional impact, morbidity, mortality,
      or management burden.
    recommended: true
attributes:
  burden_level:
    name: burden_level
    description: Coarse disease-level clinical burden category
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: burden_level
    owner: ClinicalBurden
    domain_of:
    - ClinicalBurden
    range: ClinicalBurdenLevelEnum
    required: true
  rationale:
    name: rationale
    description: Curator rationale for assigning this burden level, including what
      aspects of functional impact, morbidity, duration, management burden, or long-term
      consequence drive the assessment.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: rationale
    owner: ClinicalBurden
    domain_of:
    - ClinicalBurden
    - AlgorithmValidationStatus
    - Discussion
    range: string
    recommended: true
  evidence:
    name: evidence
    description: Evidence supporting the disease-level clinical burden assessment.
      Prefer sources that describe typical course, functional impact, morbidity, mortality,
      or management burden.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: evidence
    owner: ClinicalBurden
    domain_of:
    - PhenotypeContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - ModelMechanismLink
    - BiomarkerReadout
    - PhenotypeReadout
    - ReferenceRange
    - SurrogateEndpoint
    - ExternalAssertion
    - Finding
    - Prevalence
    - GeneCaseFraction
    - ProgressionInfo
    - ClinicalBurden
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - ImagingFinding
    - Genetic
    - Environmental
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Diagnosis
    - Inheritance
    - Variant
    - ModelingConsideration
    - ClassificationAssignment
    - Definition
    - AlgorithmValidationStatus
    - CriteriaSet
    - AssociationSignal
    - AssociationStatistics
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    - Discussion
    - GroupingCriteria
    - GroupingMember
    - DifferentiatingMechanism
    range: EvidenceItem
    recommended: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  notes:
    name: notes
    examples:
    - value: Contagious stage where symptoms appear and the bacteria can be spread
        to others.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: notes
    owner: ClinicalBurden
    domain_of:
    - GeneticContext
    - OnsetDescriptor
    - PhenotypeContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - ModelVariable
    - DifferentialDiagnosis
    - ReferenceRange
    - SurrogateEndpoint
    - SurrogateEndpointCollection
    - ExternalAssertion
    - TrackedIssue
    - Prevalence
    - GeneCaseFraction
    - ProgressionInfo
    - ClinicalBurden
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - ImagingFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    - Transmission
    - Diagnosis
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - TermMapping
    - MappingConsistency
    - ComorbidityAssociation
    - AssociationSignal
    - AssociationMetric
    - AssociationStatistics
    - MechanisticHypothesis
    - Discussion
    - Grouping
    - GroupingCriteria
    - GroupingMember
    - DifferentiatingMechanism
    range: string