DisMech Documentation

Welcome to the documentation for DisMech, the Disorder Mechanisms Knowledge Base — a structured, evidence-backed knowledge base of disease pathophysiology.

This site covers the curation guides, the conceptual explanations, the data model, and the auto-generated schema reference. For the live knowledge base itself, head to the main site.

AI-curated resource — not medical advice

DisMech content is generated and maintained by AI curation agents under human review, from publicly accessible literature and curated biomedical knowledge resources. It is a research resource and is not intended to inform medical diagnosis or treatment. See the full disclaimer.

Start here

• New to the data model? Read the Data Model overview — a curated map of the key schema classes.
• Curating an entry? Start with the Curation Primers and the How-to Guides.
• Need exact schema details? See the full Schema Reference.

Curation Primers

Short, visual guides to the modeling patterns you'll use most:

• Phenotype Association Context — scoped phenotype assertions; OMIM-like vs Orphanet-like sources; phenotype_contexts vs has_subtypes.
• Preferred Term vs Ontology Label — the two-field display/ontology contract and when to diverge.
• Modules & Conformance — conforms_to as consistency checking, not inheritance.

For the deeper conceptual background, see Contextualization and Post-composition Terms.

The main site

• dismech.monarchinitiative.org — project home
• Disorder browser — browse the knowledge base
• Detailed docs — how a disorder page is built
• GitHub repository