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Class: DifferentiatingMechanism

A mechanism or feature that distinguishes a grouping member from its siblings, as prose plus optional structured descriptors (gene, phenotype, biological process, module).

URI: dismech:class/DifferentiatingMechanism

 classDiagram
    class DifferentiatingMechanism
    click DifferentiatingMechanism href "../../classes/DifferentiatingMechanism/"
      DifferentiatingMechanism : biological_processes





        DifferentiatingMechanism --> "*" BiologicalProcessDescriptor : biological_processes
        click BiologicalProcessDescriptor href "../../classes/BiologicalProcessDescriptor/"



      DifferentiatingMechanism : description

      DifferentiatingMechanism : evidence





        DifferentiatingMechanism --> "* _recommended_" EvidenceItem : evidence
        click EvidenceItem href "../../classes/EvidenceItem/"



      DifferentiatingMechanism : gene





        DifferentiatingMechanism --> "0..1" GeneDescriptor : gene
        click GeneDescriptor href "../../classes/GeneDescriptor/"



      DifferentiatingMechanism : modifier





        DifferentiatingMechanism --> "0..1" ModifierEnum : modifier
        click ModifierEnum href "../../enums/ModifierEnum/"



      DifferentiatingMechanism : module

      DifferentiatingMechanism : notes

      DifferentiatingMechanism : phenotype_term





        DifferentiatingMechanism --> "0..1" PhenotypeDescriptor : phenotype_term
        click PhenotypeDescriptor href "../../classes/PhenotypeDescriptor/"

Slots

Name Cardinality and Range Description Inheritance
description 1
String		 Human-readable statement of the differentiating mechanism direct
gene 0..1
GeneDescriptor		 direct
phenotype_term 0..1
PhenotypeDescriptor		 The HP term for this phenotype direct
biological_processes *
BiologicalProcessDescriptor		 direct
module 0..1
String		 Reference to a mechanism module in kb/modules/ (filename stem, without direct
modifier 0..1
ModifierEnum		 Directional or qualitative modifier for a descriptor (e direct
evidence * recommended
EvidenceItem		 direct
notes 0..1
String		 direct

Usages

used by used in type used
GroupingMember differentiating_mechanisms range DifferentiatingMechanism

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type Mapped Value
self dismech:DifferentiatingMechanism
native dismech:DifferentiatingMechanism

LinkML Source

Direct

name: DifferentiatingMechanism
description: A mechanism or feature that distinguishes a grouping member from its
  siblings, as prose plus optional structured descriptors (gene, phenotype, biological
  process, module).
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- description
- gene
- phenotype_term
- biological_processes
- module
- modifier
- evidence
- notes
slot_usage:
  description:
    name: description
    description: Human-readable statement of the differentiating mechanism.
    required: true

Induced

name: DifferentiatingMechanism
description: A mechanism or feature that distinguishes a grouping member from its
  siblings, as prose plus optional structured descriptors (gene, phenotype, biological
  process, module).
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  description:
    name: description
    description: Human-readable statement of the differentiating mechanism.
    required: true
attributes:
  description:
    name: description
    description: Human-readable statement of the differentiating mechanism.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: description
    owner: DifferentiatingMechanism
    domain_of:
    - Descriptor
    - DietaryModification
    - GeneticContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - ModelVariable
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - ModelMechanismLink
    - BiomarkerReadout
    - PhenotypeReadout
    - SurrogateEndpointCollection
    - ProteinStructure
    - ExternalAssertion
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - HistopathologyFinding
    - ImagingFinding
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - FunctionalEffect
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ConditionDescriptor
    - GOEnrichment
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    - Grouping
    - GroupingCriteria
    - LogicalCriterion
    - DifferentiatingMechanism
    range: string
    required: true
  gene:
    name: gene
    examples:
    - value: '{preferred_term: MEFV}'
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: gene
    owner: DifferentiatingMechanism
    domain_of:
    - GeneticContext
    - ExperimentalPerturbation
    - Pathophysiology
    - Variant
    - LogicalCriterion
    - DifferentiatingMechanism
    range: GeneDescriptor
    inlined: true
  phenotype_term:
    name: phenotype_term
    description: The HP term for this phenotype
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: phenotype_term
    owner: DifferentiatingMechanism
    domain_of:
    - ExperimentalReadout
    - ReferenceRangeBand
    - Phenotype
    - ImagingFinding
    - LogicalCriterion
    - DifferentiatingMechanism
    range: PhenotypeDescriptor
    inlined: true
  biological_processes:
    name: biological_processes
    examples:
    - value: '[{preferred_term: TNF-alpha Production}]'
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: biological_processes
    owner: DifferentiatingMechanism
    domain_of:
    - ExperimentalPerturbation
    - ExperimentalReadout
    - Pathophysiology
    - LogicalCriterion
    - DifferentiatingMechanism
    range: BiologicalProcessDescriptor
    multivalued: true
    inlined: true
    inlined_as_list: true
  module:
    name: module
    description: Reference to a mechanism module in kb/modules/ (filename stem, without
      .yaml, optionally with a "#Node Name" anchor). Used by CONFORMS_TO_MODULE criteria
      and by differentiating mechanisms.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: module
    owner: DifferentiatingMechanism
    domain_of:
    - LogicalCriterion
    - DifferentiatingMechanism
    range: string
  modifier:
    name: modifier
    description: Directional or qualitative modifier for a descriptor (e.g., increased,
      decreased, abnormal)
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: modifier
    owner: DifferentiatingMechanism
    domain_of:
    - Descriptor
    - ImagingFinding
    - DifferentiatingMechanism
    range: ModifierEnum
  evidence:
    name: evidence
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: evidence
    owner: DifferentiatingMechanism
    domain_of:
    - PhenotypeContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - ModelMechanismLink
    - BiomarkerReadout
    - PhenotypeReadout
    - ReferenceRange
    - SurrogateEndpoint
    - ExternalAssertion
    - Finding
    - Prevalence
    - GeneCaseFraction
    - ProgressionInfo
    - ClinicalBurden
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - ImagingFinding
    - Genetic
    - Environmental
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Diagnosis
    - Inheritance
    - Variant
    - ModelingConsideration
    - ClassificationAssignment
    - Definition
    - AlgorithmValidationStatus
    - CriteriaSet
    - AssociationSignal
    - AssociationStatistics
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    - Discussion
    - GroupingCriteria
    - GroupingMember
    - DifferentiatingMechanism
    range: EvidenceItem
    recommended: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  notes:
    name: notes
    examples:
    - value: Contagious stage where symptoms appear and the bacteria can be spread
        to others.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: notes
    owner: DifferentiatingMechanism
    domain_of:
    - GeneticContext
    - OnsetDescriptor
    - PhenotypeContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - ModelVariable
    - DifferentialDiagnosis
    - ReferenceRange
    - SurrogateEndpoint
    - SurrogateEndpointCollection
    - ExternalAssertion
    - TrackedIssue
    - Prevalence
    - GeneCaseFraction
    - ProgressionInfo
    - ClinicalBurden
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - ImagingFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    - Transmission
    - Diagnosis
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - TermMapping
    - MappingConsistency
    - ComorbidityAssociation
    - AssociationSignal
    - AssociationMetric
    - AssociationStatistics
    - MechanisticHypothesis
    - Discussion
    - Grouping
    - GroupingCriteria
    - GroupingMember
    - DifferentiatingMechanism
    range: string