Class: ExperimentalControl

A comparator or control condition for an experiment, such as an isogenic wild-type line, mock perturbation, vehicle control, rescue arm, or untreated disease model.

URI: dismech:class/ExperimentalControl

 classDiagram
    class ExperimentalControl
    click ExperimentalControl href "../../classes/ExperimentalControl/"
      ExperimentalControl : description

      ExperimentalControl : evidence





        ExperimentalControl --> "* _recommended_" EvidenceItem : evidence
        click EvidenceItem href "../../classes/EvidenceItem/"



      ExperimentalControl : model_systems





        ExperimentalControl --> "*" ExperimentalModel : model_systems
        click ExperimentalModel href "../../classes/ExperimentalModel/"



      ExperimentalControl : name

      ExperimentalControl : notes

      ExperimentalControl : perturbations





        ExperimentalControl --> "*" ExperimentalPerturbation : perturbations
        click ExperimentalPerturbation href "../../classes/ExperimentalPerturbation/"

Slots

Name	Cardinality and Range	Description	Inheritance
name	1 String		direct
description	0..1 String		direct
model_systems	* ExperimentalModel	Experimental model systems used or proposed for an experiment, using the Expe...	direct
perturbations	* ExperimentalPerturbation	Gene knockouts, reaction deletions, or parameter changes modeling the disease	direct
evidence	* recommended EvidenceItem		direct
notes	0..1 String		direct

Usages

used by	used in	type	used
Experiment	controls	range	ExperimentalControl

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type	Mapped Value
self	dismech:ExperimentalControl
native	dismech:ExperimentalControl

LinkML Source

Direct

name: ExperimentalControl
description: A comparator or control condition for an experiment, such as an isogenic
  wild-type line, mock perturbation, vehicle control, rescue arm, or untreated disease
  model.
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- name
- description
- model_systems
- perturbations
- evidence
- notes
slot_usage:
  perturbations:
    name: perturbations
    range: ExperimentalPerturbation
    inlined_as_list: true

Induced

name: ExperimentalControl
description: A comparator or control condition for an experiment, such as an isogenic
  wild-type line, mock perturbation, vehicle control, rescue arm, or untreated disease
  model.
from_schema: https://w3id.org/monarch-initiative/dismech
slot_usage:
  perturbations:
    name: perturbations
    range: ExperimentalPerturbation
    inlined_as_list: true
attributes:
  name:
    name: name
    examples:
    - value: Adolescent Nephronophthisis
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    identifier: true
    alias: name
    owner: ExperimentalControl
    domain_of:
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - ModelVariable
    - SeverityTier
    - DifferentialDiagnosis
    - Subtype
    - SurrogateEndpointCollection
    - ExternalAssertion
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycleStage
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ComorbidityAssociation
    range: string
    required: true
  description:
    name: description
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: description
    owner: ExperimentalControl
    domain_of:
    - Descriptor
    - DietaryModification
    - GeneticContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - ModelVariable
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - ModelMechanismLink
    - BiomarkerReadout
    - SurrogateEndpointCollection
    - ProteinStructure
    - ExternalAssertion
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - HistopathologyFinding
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Assay
    - Diagnosis
    - Inheritance
    - Variant
    - FunctionalEffect
    - Mechanism
    - ModelingConsideration
    - Definition
    - CriteriaSet
    - ConditionDescriptor
    - GOEnrichment
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    range: string
  model_systems:
    name: model_systems
    description: Experimental model systems used or proposed for an experiment, using
      the ExperimentalModel pattern and optional NAMO alignment.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: model_systems
    owner: ExperimentalControl
    domain_of:
    - Experiment
    - ExperimentalControl
    range: ExperimentalModel
    multivalued: true
    inlined: true
    inlined_as_list: true
  perturbations:
    name: perturbations
    description: Gene knockouts, reaction deletions, or parameter changes modeling
      the disease
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: perturbations
    owner: ExperimentalControl
    domain_of:
    - Experiment
    - ExperimentalControl
    - ComputationalModel
    range: ExperimentalPerturbation
    multivalued: true
    inlined: true
    inlined_as_list: true
  evidence:
    name: evidence
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: evidence
    owner: ExperimentalControl
    domain_of:
    - PhenotypeContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - DifferentialDiagnosis
    - Subtype
    - CausalEdge
    - TreatmentMechanismTarget
    - ModelMechanismLink
    - BiomarkerReadout
    - ReferenceRange
    - SurrogateEndpoint
    - ExternalAssertion
    - Finding
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - AnimalModel
    - Treatment
    - InfectiousAgent
    - Transmission
    - Diagnosis
    - Inheritance
    - Variant
    - ModelingConsideration
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - AssociationSignal
    - AssociationStatistics
    - ComorbidityHypothesis
    - UpstreamConditionHypothesis
    - MechanisticHypothesis
    - Discussion
    range: EvidenceItem
    recommended: true
    multivalued: true
    inlined: true
    inlined_as_list: true
  notes:
    name: notes
    examples:
    - value: Contagious stage where symptoms appear and the bacteria can be spread
        to others.
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: notes
    owner: ExperimentalControl
    domain_of:
    - GeneticContext
    - OnsetDescriptor
    - PhenotypeContext
    - Dataset
    - ExperimentalModel
    - Experiment
    - ExperimentalPerturbation
    - ExperimentalReadout
    - ExperimentalControl
    - ClinicalTrial
    - ComputationalModel
    - ModelVariable
    - DifferentialDiagnosis
    - ReferenceRange
    - SurrogateEndpoint
    - SurrogateEndpointCollection
    - ExternalAssertion
    - TrackedIssue
    - Prevalence
    - ProgressionInfo
    - EpidemiologyInfo
    - Pathophysiology
    - Phenotype
    - Biochemical
    - HistopathologyFinding
    - Genetic
    - Environmental
    - Disease
    - Stage
    - AgentLifeCycle
    - AgentLifeCycleStage
    - Treatment
    - Transmission
    - Diagnosis
    - ClassificationAssignment
    - Definition
    - CriteriaSet
    - TermMapping
    - MappingConsistency
    - ComorbidityAssociation
    - AssociationSignal
    - AssociationMetric
    - AssociationStatistics
    - MechanisticHypothesis
    - Discussion
    range: string