| Experiment |
A structured experiment or protocol-level study design that can be proposed t... |
no |
| GeneticContext |
A structured description of a genetic context that modifies phenotype frequen... |
no |
| FDASurrogateEndpointCollection |
FDA surrogate endpoint table import preserving row-level source provenance |
no |
| AnimalModel |
A whole-organism animal model of the disease |
no |
| AssayDescriptor |
A descriptor for assays, bindable to OBI |
no |
| DifferentiatingMechanism |
A mechanism or feature that distinguishes a grouping member from its siblings... |
yes |
| Treatment |
|
no |
| ModelingConsideration |
|
no |
| Diagnosis |
|
no |
| ChemicalEntityDescriptor |
A descriptor for chemical entities, bindable to CHEBI |
no |
| ExperimentalModel |
A disease-relevant non-animal experimental model system — a New Approach Meth... |
no |
| ComputationalModel |
A computational or in-silico model relevant to understanding disease mechanis... |
no |
| ModuleCollection |
A curated navigation or framework record that organizes mechanism modules |
no |
| AnatomicalEntityDescriptor |
A descriptor for anatomical locations, bindable to UBERON |
no |
| AgentLifeCycle |
|
no |
| ConditionDescriptor |
A descriptor for a condition or disease, optionally bound to MONDO |
no |
| FoodDescriptor |
A descriptor for foods, beverages, nutrients, minerals, and supplements, bind... |
no |
| CellularComponentDescriptor |
A descriptor for cellular components, bindable to GO cellular component |
no |
| UpstreamConditionHypothesis |
Hypothesized upstream condition that may explain both A and B |
no |
| ExperimentalPerturbation |
A structured perturbation, intervention, or exposure used in an experiment |
no |
| AgentLifeCycleStage |
|
no |
| EnvironmentDescriptor |
A descriptor for environmental contexts/settings, bindable to ENVO |
no |
| ModelVariableDescriptor |
A descriptor mapping a model variable to an ontology term (LOINC, CHEBI, HP, ... |
no |
| BiologicalProcessDescriptor |
A descriptor for biological processes, bindable to Gene Ontology (GO) |
no |
| Grouping |
An explicit, curated union of distinct Disease entries assembled below the le... |
no |
| ModuleCollectionMember |
A mechanism module included in a ModuleCollection, with optional labels and e... |
no |
| PhenotypeDescriptor |
A descriptor for phenotypes, bindable to Human Phenotype Ontology (HP) |
no |
| BiomarkerReadout |
Links a biochemical biomarker to a pathograph node that it measures, reflects... |
no |
| ExposureDescriptor |
A descriptor for exposure events, bindable to ECTO or XCO |
no |
| MolecularFunctionDescriptor |
A descriptor for molecular functions, bindable to Gene Ontology (GO) |
no |
| Pathophysiology |
|
no |
| HistopathologyFinding |
A histopathologic finding from microscopic examination of tissue |
yes |
| GroupingCriteria |
The shared membership criteria for a grouping, pairing a human-readable descr... |
yes |
| ProteinComplexDescriptor |
A descriptor for protein complexes that gene products participate in, bindabl... |
no |
| GeneProductDescriptor |
A descriptor for gene products (proteins, fusion proteins, oncoproteins), bin... |
no |
| Stage |
|
no |
| Transmission |
|
no |
| HostDescriptor |
A descriptor for hosts in an infectious agent life cycle |
no |
| Variant |
A genetic variant associated with a disease, including coding and non-coding ... |
no |
| FunctionalEffect |
Describes the functional consequence of a genetic variant, including regulato... |
no |
| Environmental |
An environmental factor, exposure, or context relevant to disease |
no |
| InheritanceDescriptor |
A descriptor for inheritance patterns, bindable to HPO mode of inheritance te... |
no |
| CellTypeDescriptor |
A descriptor for cell types, bindable to Cell Ontology (CL) |
no |
| ExternalAssertion |
An externally curated assertion or registry record relevant to a disease or v... |
no |
| ImagingFindingDescriptor |
A descriptor for an in-vivo imaging finding, bindable to the NCIT Imaging Fin... |
no |
| PhenotypeReadout |
Links an investigation-readout phenotype (an abnormal electrophysiology, func... |
no |
| EpidemiologyInfo |
|
no |
| DifferentialDiagnosis |
A disease or condition that presents similarly to the focal disease and must ... |
yes |
| EnvironmentalMechanismTarget |
Links an environmental factor or exposure to a specific pathophysiology mecha... |
no |
| ModelVariable |
A variable in a computational model, identified by a human-readable name, wit... |
no |
| ModelMechanismLink |
Links an experimental (NAM), animal, or computational model to a specific pat... |
yes |
| Subtype |
|
no |
| CriteriaSet |
A named criteria grouping within a definition |
no |
| CriteriaItem |
A criterion element (clinical feature, test result, imaging requirement) |
no |
| Disease |
|
no |
| DiseaseDescriptor |
A descriptor for the focal disease, bindable to MONDO |
no |
| Descriptor |
Base class for structured descriptors that allow a preferred term, optional d... |
yes |
| ImagingFinding |
A finding detected by in-vivo medical imaging (MRI, CT, PET, ultrasound, etc |
yes |
| Inheritance |
|
no |
| TreatmentMechanismTarget |
Links a treatment to a specific pathophysiology mechanism node it targets |
no |
| GeneDescriptor |
A descriptor for genes, bindable to HGNC or other gene databases |
no |
| Definition |
A diagnostic or phenotype definition for the disease |
no |
| LogicalCriterion |
A node in a nested boolean membership-criteria expression |
no |
| ComorbidityHypothesis |
Mechanistic hypothesis for a comorbidity association, with rich text and embe... |
no |
| TreatmentDescriptor |
A descriptor for treatments/medical actions, bindable to NCIT clinical interv... |
no |
| RegimenDescriptor |
A descriptor for treatment regimens, bindable to NCIT |
no |
| CausalEdge |
A reference to a downstream effect or consequence in a causal relationship |
no |
| Phenotype |
|
no |
| BiomarkerDescriptor |
A descriptor for biomarkers, bindable to NCIT |
no |
| Mechanism |
|
no |
| ExperimentalControl |
A comparator or control condition for an experiment, such as an isogenic wild... |
no |
| ModelDivergence |
One typed way in which a model departs from the mechanism node it is linked t... |
yes |
| GOEnrichment |
GO enrichment results for an association signal |
no |
| MechanisticHypothesis |
Disease-level hypothesis metadata used to organize downstream causal edges in... |
no |
| SubtypeDescriptor |
A descriptor for disease subtypes, bindable to MONDO disease terms or NCIT on... |
no |
| ProteinStructure |
A 3D protein structure from PDB or AlphaFold relevant to understanding a trea... |
no |
| TriggerDescriptor |
A descriptor for triggers/causes |
no |
| LifeCycleStageDescriptor |
A descriptor for parasite life cycle stages, bindable to OPL |
no |
| ExperimentalReadout |
A structured readout or outcome measured in an experiment or reported by a mo... |
no |
| ClinicalTrial |
A clinical trial relevant to treatment or research of a disease |
yes |
| OrganismDescriptor |
A descriptor for organisms, bindable to NCBITaxon |
no |
| Assay |
|
no |
| SurrogateEndpointCollection |
A source-level collection of curated regulatory surrogate endpoint assertions |
no |
| HistopathologyFindingDescriptor |
A descriptor for histopathologic findings, bindable to the NCIT Histopatholog... |
no |
| InfectiousAgent |
|
no |
| DietaryModification |
A structured dietary addition, restriction, avoidance, or substitution used t... |
no |
| SampleTypeDescriptor |
A descriptor for biological sample types (tissue and/or cell type) |
no |
| Dataset |
A reference to a publicly available omics or phenotype dataset |
yes |