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Class: AntisenseOligonucleotideDetail

Structured attributes specific to an antisense oligonucleotide (ASO) treatment: its molecular mechanism, RNA target, splice exon (for splice-switching ASOs), backbone chemistry, and targeting conjugate. Attach via the aso_details slot on a Treatment whose therapeutic_modality is ANTISENSE_OLIGONUCLEOTIDE.

URI: dismech:class/AntisenseOligonucleotideDetail

 classDiagram
    class AntisenseOligonucleotideDetail
    click AntisenseOligonucleotideDetail href "../../classes/AntisenseOligonucleotideDetail/"
      AntisenseOligonucleotideDetail : aso_chemistry





        AntisenseOligonucleotideDetail --> "0..1" AsoChemistryEnum : aso_chemistry
        click AsoChemistryEnum href "../../enums/AsoChemistryEnum/"



      AntisenseOligonucleotideDetail : aso_mechanism





        AntisenseOligonucleotideDetail --> "0..1" AsoMechanismEnum : aso_mechanism
        click AsoMechanismEnum href "../../enums/AsoMechanismEnum/"



      AntisenseOligonucleotideDetail : conjugation





        AntisenseOligonucleotideDetail --> "0..1" AsoConjugationEnum : conjugation
        click AsoConjugationEnum href "../../enums/AsoConjugationEnum/"



      AntisenseOligonucleotideDetail : target_exon

      AntisenseOligonucleotideDetail : target_gene





        AntisenseOligonucleotideDetail --> "0..1" GeneDescriptor : target_gene
        click GeneDescriptor href "../../classes/GeneDescriptor/"



      AntisenseOligonucleotideDetail : target_transcript

Slots

Name Cardinality and Range Description Inheritance
aso_mechanism 0..1
AsoMechanismEnum		 Molecular mechanism of action of an antisense oligonucleotide direct
target_gene 0..1
GeneDescriptor		 The gene whose transcript an antisense oligonucleotide targets (bindable to H... direct
target_transcript 0..1
String		 The specific transcript, pre-mRNA element, or sequence motif targeted by an a... direct
target_exon 0..1
String		 The exon (or exons) modulated by a splice-switching antisense oligonucleotide... direct
aso_chemistry 0..1
AsoChemistryEnum		 Backbone / sugar chemistry of an antisense oligonucleotide direct
conjugation 0..1
AsoConjugationEnum		 Targeting ligand or conjugate attached to an antisense oligonucleotide direct

Usages

used by used in type used
Treatment aso_details range AntisenseOligonucleotideDetail

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type Mapped Value
self dismech:AntisenseOligonucleotideDetail
native dismech:AntisenseOligonucleotideDetail

LinkML Source

Direct

name: AntisenseOligonucleotideDetail
description: 'Structured attributes specific to an antisense oligonucleotide (ASO)
  treatment: its molecular mechanism, RNA target, splice exon (for splice-switching
  ASOs), backbone chemistry, and targeting conjugate. Attach via the aso_details slot
  on a Treatment whose therapeutic_modality is ANTISENSE_OLIGONUCLEOTIDE.'
from_schema: https://w3id.org/monarch-initiative/dismech
slots:
- aso_mechanism
- target_gene
- target_transcript
- target_exon
- aso_chemistry
- conjugation

Induced

name: AntisenseOligonucleotideDetail
description: 'Structured attributes specific to an antisense oligonucleotide (ASO)
  treatment: its molecular mechanism, RNA target, splice exon (for splice-switching
  ASOs), backbone chemistry, and targeting conjugate. Attach via the aso_details slot
  on a Treatment whose therapeutic_modality is ANTISENSE_OLIGONUCLEOTIDE.'
from_schema: https://w3id.org/monarch-initiative/dismech
attributes:
  aso_mechanism:
    name: aso_mechanism
    description: Molecular mechanism of action of an antisense oligonucleotide
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: aso_mechanism
    owner: AntisenseOligonucleotideDetail
    domain_of:
    - AntisenseOligonucleotideDetail
    range: AsoMechanismEnum
  target_gene:
    name: target_gene
    description: The gene whose transcript an antisense oligonucleotide targets (bindable
      to HGNC).
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: target_gene
    owner: AntisenseOligonucleotideDetail
    domain_of:
    - AntisenseOligonucleotideDetail
    range: GeneDescriptor
    inlined: true
  target_transcript:
    name: target_transcript
    description: The specific transcript, pre-mRNA element, or sequence motif targeted
      by an antisense oligonucleotide (e.g., a RefSeq/Ensembl transcript ID, "SMN2
      ISS-N1", or "APOB mRNA").
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: target_transcript
    owner: AntisenseOligonucleotideDetail
    domain_of:
    - AntisenseOligonucleotideDetail
    range: string
  target_exon:
    name: target_exon
    description: The exon (or exons) modulated by a splice-switching antisense oligonucleotide,
      expressed in human-readable form (e.g., "exon 51", "exon 7").
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: target_exon
    owner: AntisenseOligonucleotideDetail
    domain_of:
    - AntisenseOligonucleotideDetail
    range: string
  aso_chemistry:
    name: aso_chemistry
    description: Backbone / sugar chemistry of an antisense oligonucleotide
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: aso_chemistry
    owner: AntisenseOligonucleotideDetail
    domain_of:
    - AntisenseOligonucleotideDetail
    range: AsoChemistryEnum
  conjugation:
    name: conjugation
    description: Targeting ligand or conjugate attached to an antisense oligonucleotide
    from_schema: https://w3id.org/monarch-initiative/dismech
    rank: 1000
    alias: conjugation
    owner: AntisenseOligonucleotideDetail
    domain_of:
    - AntisenseOligonucleotideDetail
    range: AsoConjugationEnum