Enum: AsoChemistryEnum

Backbone / sugar chemistry of an antisense oligonucleotide. Determines nuclease resistance, binding affinity, and whether the ASO supports RNase H recruitment (gapmer designs) or acts purely by steric occupancy.

URI: dismech:enum/AsoChemistryEnum

Permissible Values

Value	Meaning	Description	Additional Info
PHOSPHOROTHIOATE	CHEBI:76674	Phosphorothioate (PS) backbone modification conferring nuclease resistance; c...	Title: Phosphorothioate backbone
PHOSPHORODIAMIDATE_MORPHOLINO	None	Morpholino backbone (PMO); charge-neutral, steric-block/splice-switching chem...	Title: Phosphorodiamidate morpholino (PMO)
TWO_PRIME_O_METHYL	None	2'-O-methyl (2'-OMe) ribose modification	Title: 2'-O-methyl
TWO_PRIME_O_METHOXYETHYL	None	2'-O-methoxyethyl (2'-MOE) ribose modification (e	Title: 2'-O-methoxyethyl (2'-MOE)
LOCKED_NUCLEIC_ACID	None	Locked nucleic acid bridged-bicyclic sugar modification	Title: Locked nucleic acid (LNA)
CONSTRAINED_ETHYL	None	Constrained ethyl (cEt) bridged sugar modification	Title: Constrained ethyl (cEt)
OTHER	None	Chemistry not covered by the above categories

Slots

Name	Description
aso_chemistry	Backbone / sugar chemistry of an antisense oligonucleotide

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: AsoChemistryEnum
description: Backbone / sugar chemistry of an antisense oligonucleotide. Determines
  nuclease resistance, binding affinity, and whether the ASO supports RNase H recruitment
  (gapmer designs) or acts purely by steric occupancy.
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  PHOSPHOROTHIOATE:
    text: PHOSPHOROTHIOATE
    description: Phosphorothioate (PS) backbone modification conferring nuclease resistance;
      common base chemistry for RNase H ASOs
    meaning: CHEBI:76674
    title: Phosphorothioate backbone
    aliases:
    - phosphorothioate oligonucleotide
  PHOSPHORODIAMIDATE_MORPHOLINO:
    text: PHOSPHORODIAMIDATE_MORPHOLINO
    description: Morpholino backbone (PMO); charge-neutral, steric-block/splice-switching
      chemistry (e.g., eteplirsen, golodirsen)
    title: Phosphorodiamidate morpholino (PMO)
  TWO_PRIME_O_METHYL:
    text: TWO_PRIME_O_METHYL
    description: 2'-O-methyl (2'-OMe) ribose modification
    title: 2'-O-methyl
  TWO_PRIME_O_METHOXYETHYL:
    text: TWO_PRIME_O_METHOXYETHYL
    description: 2'-O-methoxyethyl (2'-MOE) ribose modification (e.g., nusinersen,
      inotersen, eplontersen)
    title: 2'-O-methoxyethyl (2'-MOE)
  LOCKED_NUCLEIC_ACID:
    text: LOCKED_NUCLEIC_ACID
    description: Locked nucleic acid bridged-bicyclic sugar modification
    title: Locked nucleic acid (LNA)
  CONSTRAINED_ETHYL:
    text: CONSTRAINED_ETHYL
    description: Constrained ethyl (cEt) bridged sugar modification
    title: Constrained ethyl (cEt)
  OTHER:
    text: OTHER
    description: Chemistry not covered by the above categories