Talks and Posters
Public talks and posters about DisMech, and about the NAM (New Approach Methodology) work it connects to. Each entry links to an archived copy of the slides, which is a Zenodo DOI wherever one exists. Reuse a slide by citing its DOI rather than copying the deck.
This page lists only material presented publicly. Internal and funder-facing decks are not listed here.
Disease mechanisms and regulatory science
| Date | Talk | Venue | Slides |
|---|---|---|---|
| 2026-04-03 | AI-Driven Approaches to Validate NAMs and Reduce Animal Dependency in Biomedical Research: The NAMOlution of Regulatory Science (Melissa Haendel) | Triangle CERSI | PDF (trianglecersi.org) |
| 2026-05-18 | Assembling mechanistic evidence for rare disease surrogate endpoints: the role of AI and NAMs (Chris Mungall) | FDA / Triangle CERSI Workshop: Advancing Novel Surrogate Endpoints for Rare Disease Drug Development | doi:10.5281/zenodo.20682988 |
| 2026-10-28 | Making New Approach Methodologies (NAMs) Computable for Mechanistic Discovery and Regulatory Decisionmaking Through NAM Ontology (NAMO) (poster; Korn, Hench, McMurry, Mungall, Haendel) | ASCCT 15th Annual Meeting, Durham, NC | doi:10.5281/zenodo.23582135 |
The surrogate-endpoint talk was written to follow on from NAMOlution. NAMOlution sets out why NAMs need shared semantics and how a NAM study is designed around its context of use. The surrogate-endpoint talk asks whether a biomarker sits on the causal path to a clinical outcome, using DisMech's causal graphs and the surrogate endpoints in the FDA's approval tables. Its worked example is Fabry disease: the accepted renal surrogate (GL-3 clearance in kidney peritubular capillaries) measures one branch of the mechanism, and iPSC-derived cardiomyocyte models could supply evidence for the cardiac branch, which the surrogate does not assess.
DisMech and agentic curation
| Date | Talk | Venue | Slides |
|---|---|---|---|
| 2026-02-19 | Unlocking Disease Mechanisms: Agentic AI for Clinical Knowledge (keynote; Chris Mungall) | TMC AI Summit 2026, Houston, TX | doi:10.5281/zenodo.18720444 |
| 2026-07-17 | Interchangeable Parts: Agentic AI for Data Modeling, Curation, and Validation (Harry Caufield) | ICBO 2026, Cell Type Knowledge in the Age of Foundation Models & Agentic AI workshop | Google Slides |
| 2026-10-08 | Practical tools and frameworks for agentic curation (Chris Mungall) | Ontology-led curation with AI, EMBL-EBI Industry Programme workshop, Hinxton, UK | doi:10.5281/zenodo.23627886 |
| 2026-10-23 | Show me the receipts: patterns for truth verification in agentic knowledge generation (lightning talk; Chris Mungall) | JBIMS Fall mini-workshop: Veridical Data Science and Reproducible AI, UC Berkeley | doi:10.5281/zenodo.23628028 |
| 2026-10-27 | Agentic Curation of the Pathophysiome (Chris Mungall) | GlySpace Alliance Webinar (GlyGen), online | doi:10.5281/zenodo.23695542 |
Adding a talk
Add a row in date order to the section that fits. Give the talk title exactly as it appears on the slides, the speaker, the venue (linked if it has a page), and an archived link to the slides. Prefer a Zenodo DOI; link a venue-hosted copy when the slides are not on Zenodo, and a Google Slides link only as a last resort, because those are not guaranteed to stay public.