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Slot: target_mechanisms

Pathophysiology mechanism nodes that this treatment targets or modulates. Links a treatment to specific steps in the disease's causal graph, enabling inference about which downstream phenotypes should respond to therapy.

URI: dismech:slot/target_mechanisms Alias: target_mechanisms

Applicable Classes

Name Description Modifies Slot
Treatment no

Properties

Type and Range

Property Value
Range TreatmentMechanismTarget
Domain Of Treatment

Cardinality and Requirements

Property Value
Multivalued Yes

Comments

  • Target names should match pathophysiology entry names in the same disease file
  • Complements target_phenotypes by explaining WHERE in the causal chain the drug acts
  • Analogous to DrugMechDB paths but anchored to dismech pathophysiology nodes

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type Mapped Value
self dismech:target_mechanisms
native dismech:target_mechanisms

LinkML Source

name: target_mechanisms
description: Pathophysiology mechanism nodes that this treatment targets or modulates.
  Links a treatment to specific steps in the disease's causal graph, enabling inference
  about which downstream phenotypes should respond to therapy.
comments:
- Target names should match pathophysiology entry names in the same disease file
- Complements target_phenotypes by explaining WHERE in the causal chain the drug acts
- Analogous to DrugMechDB paths but anchored to dismech pathophysiology nodes
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
alias: target_mechanisms
domain_of:
- Treatment
range: TreatmentMechanismTarget
multivalued: true
inlined: true
inlined_as_list: true