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Slot: mhc_term

Optional MRO (MHC Restriction Ontology) term for an HLA/MHC allele, serotype, haplotype, or presenting protein complex. On a Genetic entry, complements gene_term (which binds the locus in HGNC, e.g. HLA-DQA1 or HLA-B) with the allele, serotype, haplotype, or heterodimer specificity (e.g. MRO:0000283 HLA-DQ2 serotype, MRO:0001284 HLA-DRB1*03:01 protein complex). On a TreatmentEffectModifier with effect_modifier_type: GENOTYPE, grounds an HLA-restricted vaccine or immunotherapy responder/non-responder stratum.

URI: dismech:slot/mhc_term Alias: mhc_term

Applicable Classes

Name Description Modifies Slot
TreatmentEffectModifier A reported difference in a treatment's effect between patient subgroups: the ... no
Genetic no

Properties

Type and Range

Property Value
Range MHCDescriptor
Domain Of Genetic, TreatmentEffectModifier

Cardinality and Requirements

Property Value

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

Mappings

Mapping Type Mapped Value
self dismech:mhc_term
native dismech:mhc_term

LinkML Source

name: mhc_term
description: 'Optional MRO (MHC Restriction Ontology) term for an HLA/MHC allele,
  serotype, haplotype, or presenting protein complex. On a Genetic entry, complements
  `gene_term` (which binds the locus in HGNC, e.g. HLA-DQA1 or HLA-B) with the allele,
  serotype, haplotype, or heterodimer specificity (e.g. `MRO:0000283` HLA-DQ2 serotype,
  `MRO:0001284` HLA-DRB1*03:01 protein complex). On a TreatmentEffectModifier with
  `effect_modifier_type: GENOTYPE`, grounds an HLA-restricted vaccine or immunotherapy
  responder/non-responder stratum.'
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
alias: mhc_term
domain_of:
- Genetic
- TreatmentEffectModifier
range: MHCDescriptor
inlined: true