Enum: TargetingLigandEnum

Targeting ligand attached to a therapeutic agent, or to the carrier particle that holds it, to direct tissue or cell uptake or to improve pharmacokinetics. Distinct from delivery_platform, which records what carries the agent at all as opposed to a nanoparticle, a viral vector, or nothing. The two axes are orthogonal in both directions: an unconjugated oligonucleotide may still be formulated in a lipid nanoparticle (e.g., patisiran), and a nanoparticle may itself carry a ligand on its surface (e.g., an antibody-coated mRNA lipid nanoparticle).

URI: dismech:enum/TargetingLigandEnum

Permissible Values

Value	Meaning	Description	Additional Info
UNCONJUGATED	None	No targeting ligand - a naked ASO, or a carrier particle with an unmodified s...
GALNAC	CHEBI:28037	Tri-antennary N-acetylgalactosamine conjugate for hepatocyte (ASGR-mediated) ...	Title: GalNAc-conjugated
LIPID	None	Lipid or fatty-acid conjugate
PEPTIDE	None	Cell-penetrating or targeting peptide conjugate
ANTIBODY	None	Antibody or antibody fragment as the targeting ligand - an antibody-oligonucl...
MANNOSE	None	Mannose or a mannosylated surface directing uptake via the macrophage mannose...	Title: Mannose / mannosylated
OTHER	None	Targeting ligand not covered by the above categories

Slots

Name	Description
conjugation	Deprecated alias of targeting_ligand, retained so entries authored before the...
targeting_ligand	Targeting ligand attached to the active agent, or to the carrier particle hol...

Aliases

• OligonucleotideConjugationEnum
• AsoConjugationEnum

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: TargetingLigandEnum
description: 'Targeting ligand attached to a therapeutic agent, or to the carrier
  particle that holds it, to direct tissue or cell uptake or to improve pharmacokinetics.
  Distinct from delivery_platform, which records what carries the agent at all as
  opposed to a nanoparticle, a viral vector, or nothing. The two axes are orthogonal
  in both directions: an unconjugated oligonucleotide may still be formulated in a
  lipid nanoparticle (e.g., patisiran), and a nanoparticle may itself carry a ligand
  on its surface (e.g., an antibody-coated mRNA lipid nanoparticle).'
from_schema: https://w3id.org/monarch-initiative/dismech
aliases:
- OligonucleotideConjugationEnum
- AsoConjugationEnum
rank: 1000
permissible_values:
  UNCONJUGATED:
    text: UNCONJUGATED
    description: No targeting ligand - a naked ASO, or a carrier particle with an
      unmodified surface
  GALNAC:
    text: GALNAC
    description: Tri-antennary N-acetylgalactosamine conjugate for hepatocyte (ASGR-mediated)
      uptake (e.g., eplontersen, olezarsen)
    meaning: CHEBI:28037
    title: GalNAc-conjugated
    aliases:
    - N-acetyl-D-galactosamine
  LIPID:
    text: LIPID
    description: Lipid or fatty-acid conjugate
  PEPTIDE:
    text: PEPTIDE
    description: Cell-penetrating or targeting peptide conjugate
  ANTIBODY:
    text: ANTIBODY
    description: Antibody or antibody fragment as the targeting ligand - an antibody-oligonucleotide
      conjugate (AOC), or an antibody coupled to the surface of a carrier particle
      for receptor-targeted delivery
  MANNOSE:
    text: MANNOSE
    description: Mannose or a mannosylated surface directing uptake via the macrophage
      mannose receptor (MRC1/CD206)
    title: Mannose / mannosylated
    comments:
    - Left unmapped, like every value here except GALNAC. CHEBI:37684 (mannose) names
      the sugar rather than its use as a targeting ligand, and the enum's other ligand
      classes (lipid, peptide, antibody) have no ontology term for the targeting role
      either.
  OTHER:
    text: OTHER
    description: Targeting ligand not covered by the above categories