Enum: OligonucleotideConjugationEnum

Targeting ligand covalently attached to a therapeutic oligonucleotide to direct tissue uptake or improve pharmacokinetics. Distinct from delivery_platform, which records whether the oligonucleotide is carried by a conjugate at all as opposed to a nanoparticle, a viral vector, or nothing: an unconjugated oligonucleotide may still be formulated in a lipid nanoparticle (e.g., patisiran).

URI: dismech:enum/OligonucleotideConjugationEnum

Permissible Values

Value	Meaning	Description	Additional Info
UNCONJUGATED	None	No targeting conjugate (naked ASO)
GALNAC	CHEBI:28037	Tri-antennary N-acetylgalactosamine conjugate for hepatocyte (ASGR-mediated) ...	Title: GalNAc-conjugated
LIPID	None	Lipid or fatty-acid conjugate
PEPTIDE	None	Cell-penetrating or targeting peptide conjugate
ANTIBODY	None	Antibody-oligonucleotide conjugate (AOC) for receptor-targeted delivery
OTHER	None	Conjugate not covered by the above categories

Slots

Name	Description
conjugation	Targeting ligand covalently attached to a therapeutic oligonucleotide

Aliases

• AsoConjugationEnum

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: OligonucleotideConjugationEnum
description: 'Targeting ligand covalently attached to a therapeutic oligonucleotide
  to direct tissue uptake or improve pharmacokinetics. Distinct from delivery_platform,
  which records whether the oligonucleotide is carried by a conjugate at all as opposed
  to a nanoparticle, a viral vector, or nothing: an unconjugated oligonucleotide may
  still be formulated in a lipid nanoparticle (e.g., patisiran).'
from_schema: https://w3id.org/monarch-initiative/dismech
aliases:
- AsoConjugationEnum
rank: 1000
permissible_values:
  UNCONJUGATED:
    text: UNCONJUGATED
    description: No targeting conjugate (naked ASO)
  GALNAC:
    text: GALNAC
    description: Tri-antennary N-acetylgalactosamine conjugate for hepatocyte (ASGR-mediated)
      uptake (e.g., eplontersen, olezarsen)
    meaning: CHEBI:28037
    title: GalNAc-conjugated
    aliases:
    - N-acetyl-D-galactosamine
  LIPID:
    text: LIPID
    description: Lipid or fatty-acid conjugate
  PEPTIDE:
    text: PEPTIDE
    description: Cell-penetrating or targeting peptide conjugate
  ANTIBODY:
    text: ANTIBODY
    description: Antibody-oligonucleotide conjugate (AOC) for receptor-targeted delivery
  OTHER:
    text: OTHER
    description: Conjugate not covered by the above categories