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Enum: ModuleCategoryEnum

Areas of study a mechanism module is relevant to. A category asserts "this module is relevant to this area of study" — it is a discovery and browsing aid, not a mechanistic claim and not a classification of the diseases that conform to the module. Multivalued and deliberately non-exclusive: a drug-toxicity module is both TOXICOLOGY and PHARMACOLOGY, and an antiviral drug-target module is both PHARMACOLOGY and INFECTIOUS_DISEASE. Applied through the module_categories slot, which is intended for entries under kb/modules/.

URI: dismech:enum/ModuleCategoryEnum

Permissible Values

Value Meaning Description Additional Info
TOXICOLOGY None Injury caused by exposure to a xenobiotic — environmental toxicants, poisons,... Title: Toxicology
PHARMACOLOGY None Drug mechanism of action and therapeutic targeting: modules built around a mo... Title: Pharmacology
ONCOLOGY None Tumor biology and cancer therapeutics — the hallmark-of-cancer capability mod... Title: Oncology
INFECTIOUS_DISEASE None Host-pathogen mechanism and antimicrobial therapy: pathogen entry, replicatio... Title: Infectious disease
IMMUNOLOGY None Immune-mediated mechanism — innate and adaptive immune activation, autoimmuni... Title: Immunology
NEUROSCIENCE None Nervous-system mechanism across the central, peripheral, and sensory systems:... Title: Neuroscience
DEVELOPMENTAL_BIOLOGY None Morphogenesis and embryonic patterning — signalling gradients, segmentation, ... Title: Developmental biology
METABOLISM None Intermediary metabolism, bioenergetics, and cellular quality control of metab... Title: Metabolism
AGING None Geroscience mechanism — the hallmarks of aging and the age-associated process... Title: Aging

Slots

Name Description
module_categories Areas of study this mechanism module is relevant to, drawn from ModuleCategor...

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: ModuleCategoryEnum
description: 'Areas of study a mechanism module is relevant to. A category asserts
  "this module is relevant to this area of study" — it is a discovery and browsing
  aid, not a mechanistic claim and not a classification of the diseases that conform
  to the module. Multivalued and deliberately non-exclusive: a drug-toxicity module
  is both TOXICOLOGY and PHARMACOLOGY, and an antiviral drug-target module is both
  PHARMACOLOGY and INFECTIOUS_DISEASE. Applied through the `module_categories` slot,
  which is intended for entries under `kb/modules/`.'
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  TOXICOLOGY:
    text: TOXICOLOGY
    description: Injury caused by exposure to a xenobiotic — environmental toxicants,
      poisons, occupational and dietary exposures, and adverse drug reactions modelled
      as mechanism rather than as an outcome. Includes drug-toxicity modules and any
      module whose trigger arm carries a toxicant or drug exposure.
    title: Toxicology
  PHARMACOLOGY:
    text: PHARMACOLOGY
    description: 'Drug mechanism of action and therapeutic targeting: modules built
      around a molecular drug target, a therapeutic modality, or an acquired-resistance
      pathway that gates drug choice. Typically carries the target_mechanisms drug
      pattern.'
    title: Pharmacology
  ONCOLOGY:
    text: ONCOLOGY
    description: Tumor biology and cancer therapeutics — the hallmark-of-cancer capability
      modules, tumor-microenvironment mechanisms, and cancer-specific therapeutic
      vulnerabilities and resistance patterns.
    title: Oncology
  INFECTIOUS_DISEASE:
    text: INFECTIOUS_DISEASE
    description: 'Host-pathogen mechanism and antimicrobial therapy: pathogen entry,
      replication, persistence and immune evasion, together with the antibacterial,
      antifungal, and antiviral drug-target modules.'
    title: Infectious disease
  IMMUNOLOGY:
    text: IMMUNOLOGY
    description: Immune-mediated mechanism — innate and adaptive immune activation,
      autoimmunity, hypersensitivity, chronic inflammation, and the immune contribution
      to tissue injury and repair.
    title: Immunology
  NEUROSCIENCE:
    text: NEUROSCIENCE
    description: 'Nervous-system mechanism across the central, peripheral, and sensory
      systems: neurodegeneration, synaptic and circuit dysfunction, excitability,
      neurodevelopmental patterning of the brain, and neural waste clearance.'
    title: Neuroscience
  DEVELOPMENTAL_BIOLOGY:
    text: DEVELOPMENTAL_BIOLOGY
    description: Morphogenesis and embryonic patterning — signalling gradients, segmentation,
      cell-fate specification, and migration defects whose lesion acts during development
      rather than in mature tissue.
    title: Developmental biology
  METABOLISM:
    text: METABOLISM
    description: 'Intermediary metabolism, bioenergetics, and cellular quality control
      of metabolic substrate: inborn errors of metabolism, mitochondrial and lysosomal
      function, nutrient sensing, and storage or intoxication phenotypes.'
    title: Metabolism
  AGING:
    text: AGING
    description: Geroscience mechanism — the hallmarks of aging and the age-associated
      processes (senescence, telomere attrition, stem-cell exhaustion, proteostasis
      and genome-maintenance decline) that drive late-onset disease.
    title: Aging