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Enum: ModelReadoutDirectionEnum

Direction of a measured effect in an experimental, animal, or computational model, relative to the model's control or comparator arm. Complements BiomarkerReadoutDirectionEnum, which describes the direction of a clinical biomarker's association with an endpoint rather than the direction of an experimental measurement.

URI: dismech:enum/ModelReadoutDirectionEnum

Permissible Values

Value Meaning Description Additional Info
INCREASED None The readout is higher in the model condition than in the comparator Title: Increased
DECREASED None The readout is lower in the model condition than in the comparator Title: Decreased
UNCHANGED None The readout does not differ materially from the comparator Title: Unchanged
RESTORED None The readout returns toward the comparator/wild-type value, typically in a res... Title: Restored
ABOLISHED None The readout is lost or reduced to background in the model condition Title: Abolished
ALTERED None The readout differs from the comparator in a way that is not monotonic (e Title: Altered

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: ModelReadoutDirectionEnum
description: Direction of a measured effect in an experimental, animal, or computational
  model, relative to the model's control or comparator arm. Complements BiomarkerReadoutDirectionEnum,
  which describes the direction of a clinical biomarker's *association* with an endpoint
  rather than the direction of an experimental measurement.
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  INCREASED:
    text: INCREASED
    description: The readout is higher in the model condition than in the comparator
    title: Increased
  DECREASED:
    text: DECREASED
    description: The readout is lower in the model condition than in the comparator
    title: Decreased
  UNCHANGED:
    text: UNCHANGED
    description: The readout does not differ materially from the comparator. A genuine
      negative result, not missing data; omit `direction` entirely when the measurement
      was not made or not reported.
    title: Unchanged
  RESTORED:
    text: RESTORED
    description: The readout returns toward the comparator/wild-type value, typically
      in a rescue, correction, or treatment arm.
    title: Restored
  ABOLISHED:
    text: ABOLISHED
    description: The readout is lost or reduced to background in the model condition
    title: Abolished
  ALTERED:
    text: ALTERED
    description: The readout differs from the comparator in a way that is not monotonic
      (e.g. a shifted distribution or changed kinetics). Prefer a directional value
      when one applies.
    title: Altered