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Enum: ModelMechanismRelationshipEnum

Controlled relationship between an experimental, animal, or computational model and the pathophysiology node it is linked to. Distinguishes a model that reproduces a mechanism from one that merely manipulates or measures it, and gives negative results (a model that does NOT reproduce the human mechanism) a first-class home rather than leaving them in prose.

URI: dismech:enum/ModelMechanismRelationshipEnum

Permissible Values

Value Meaning Description Additional Info
RECAPITULATES None The model reproduces the linked mechanism, such that observations in the mode... Title: Recapitulates
PARTIALLY_RECAPITULATES None The model reproduces some but not all of the linked mechanism Title: Partially recapitulates
FAILS_TO_RECAPITULATE None The model does NOT reproduce the linked mechanism Title: Fails to recapitulate
PERTURBS None The model manipulates the linked mechanism (knockout, knockdown, overexpressi... Title: Perturbs
MEASURES None The model provides a readout of the linked mechanism without claiming to repr... Title: Measures
RESCUES None The model demonstrates reversal or correction of the linked mechanism, typica... Title: Rescues

Slots

Name Description
relationship What this model does to the linked mechanism: reproduces it, manipulates it, ...

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: ModelMechanismRelationshipEnum
description: Controlled relationship between an experimental, animal, or computational
  model and the pathophysiology node it is linked to. Distinguishes a model that reproduces
  a mechanism from one that merely manipulates or measures it, and gives negative
  results (a model that does NOT reproduce the human mechanism) a first-class home
  rather than leaving them in prose.
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  RECAPITULATES:
    text: RECAPITULATES
    description: The model reproduces the linked mechanism, such that observations
      in the model are taken to be informative about the human mechanism.
    title: Recapitulates
  PARTIALLY_RECAPITULATES:
    text: PARTIALLY_RECAPITULATES
    description: The model reproduces some but not all of the linked mechanism. Use
      `limitations` to state which facets are and are not reproduced.
    title: Partially recapitulates
  FAILS_TO_RECAPITULATE:
    text: FAILS_TO_RECAPITULATE
    description: The model does NOT reproduce the linked mechanism. This is a substantive
      negative claim and the structural signal for a HUMAN_MODEL_MISMATCH discussion;
      it requires `limitations` and supporting `evidence`.
    title: Fails to recapitulate
  PERTURBS:
    text: PERTURBS
    description: The model manipulates the linked mechanism (knockout, knockdown,
      overexpression, chemical challenge) without itself being a claim that the full
      mechanism is reproduced.
    title: Perturbs
  MEASURES:
    text: MEASURES
    description: The model provides a readout of the linked mechanism without claiming
      to reproduce or perturb it.
    title: Measures
  RESCUES:
    text: RESCUES
    description: The model demonstrates reversal or correction of the linked mechanism,
      typically a genetic-correction, drug-rescue, or isogenic-repair arm.
    title: Rescues