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Enum: ModelFidelityEnum

Curator assessment of how faithfully a model captures the linked human mechanism. Deliberately coarse: this is a translational-validity caveat, not a metric. Pair with limitations for the specific caveat.

URI: dismech:enum/ModelFidelityEnum

Permissible Values

Value Meaning Description Additional Info
HIGH None Human-derived or otherwise closely matched system reproducing the mechanism w... Title: High
MODERATE None Reproduces the mechanism with known and material divergences from human biolo... Title: Moderate
LOW None Informative but with divergences substantial enough that findings should not ... Title: Low
UNKNOWN None Correspondence to the human mechanism has not been established Title: Unknown

Slots

Name Description
fidelity Curator assessment of how faithfully this model captures the linked human mec...

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: ModelFidelityEnum
description: 'Curator assessment of how faithfully a model captures the linked human
  mechanism. Deliberately coarse: this is a translational-validity caveat, not a metric.
  Pair with `limitations` for the specific caveat.'
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  HIGH:
    text: HIGH
    description: Human-derived or otherwise closely matched system reproducing the
      mechanism with well-characterized correspondence to human disease.
    title: High
  MODERATE:
    text: MODERATE
    description: Reproduces the mechanism with known and material divergences from
      human biology (species differences, supraphysiological expression, reduced cellular
      complexity).
    title: Moderate
  LOW:
    text: LOW
    description: Informative but with divergences substantial enough that findings
      should not be transferred to human disease without corroboration.
    title: Low
  UNKNOWN:
    text: UNKNOWN
    description: Correspondence to the human mechanism has not been established. Prefer
      this over guessing a tier.
    title: Unknown