Enum: IARCCarcinogenGroupEnum

Carcinogenicity classification of an agent by the IARC Monographs on the Identification of Carcinogenic Hazards to Humans (International Agency for Research on Cancer, WHO). Encodes the group set established by the Preamble as amended in January 2019.

This is a hazard identification, not a risk assessment. The group states how strong the evidence is that the agent can cause cancer under some circumstance — it says nothing about potency, exposure level, or how much cancer the agent actually causes in a population. Group 1 contains both plutonium and processed meat. Curators must not paraphrase a group as a statement of risk, and a Group 1 listing is not by itself evidence that a particular disease entry's exposure caused a particular cancer.

Groups are assigned to an agent (or a mixture, or an exposure circumstance such as "painter, occupational exposure as a"), so this belongs on the exposure, never on the disease. Note also that a group applies to the agent overall; the specific tumour sites with sufficient evidence are stated separately in the Monograph and should go in notes if they matter.

URI: dismech:enum/IARCCarcinogenGroupEnum

Permissible Values

Value	Meaning	Description	Additional Info
GROUP_1	None	Group 1 - Carcinogenic to humans
GROUP_2A	None	Group 2A - Probably carcinogenic to humans
GROUP_2B	None	Group 2B - Possibly carcinogenic to humans
GROUP_3	None	Group 3 - Not classifiable as to its carcinogenicity to humans
GROUP_4	None	Group 4 - Probably not carcinogenic to humans	DEPRECATED

Slots

Name	Description
classification_value

See Also

• https://monographs.iarc.who.int/agents-classified-by-the-iarc/

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: IARCCarcinogenGroupEnum
description: 'Carcinogenicity classification of an agent by the IARC Monographs on
  the Identification of Carcinogenic Hazards to Humans (International Agency for Research
  on Cancer, WHO). Encodes the group set established by the Preamble as amended in
  January 2019.

  **This is a hazard identification, not a risk assessment.** The group states how
  strong the evidence is that the agent *can* cause cancer under some circumstance
  — it says nothing about potency, exposure level, or how much cancer the agent actually
  causes in a population. Group 1 contains both plutonium and processed meat. Curators
  must not paraphrase a group as a statement of risk, and a Group 1 listing is not
  by itself evidence that a particular disease entry''s exposure caused a particular
  cancer.

  Groups are assigned to an *agent* (or a mixture, or an exposure circumstance such
  as "painter, occupational exposure as a"), so this belongs on the exposure, never
  on the disease. Note also that a group applies to the agent overall; the specific
  tumour sites with sufficient evidence are stated separately in the Monograph and
  should go in ``notes`` if they matter.'
from_schema: https://w3id.org/monarch-initiative/dismech
source: https://monographs.iarc.who.int/iarc-monographs-preamble-preamble-to-the-iarc-monographs/
see_also:
- https://monographs.iarc.who.int/agents-classified-by-the-iarc/
rank: 1000
permissible_values:
  GROUP_1:
    text: GROUP_1
    description: Group 1 - Carcinogenic to humans. Sufficient evidence of carcinogenicity
      in humans, or (exceptionally) sufficient evidence in experimental animals plus
      strong mechanistic evidence in exposed humans.
  GROUP_2A:
    text: GROUP_2A
    description: Group 2A - Probably carcinogenic to humans. Typically limited evidence
      in humans together with sufficient evidence in experimental animals, or strong
      mechanistic evidence.
  GROUP_2B:
    text: GROUP_2B
    description: Group 2B - Possibly carcinogenic to humans. Limited evidence in humans
      and less than sufficient evidence in experimental animals, or sufficient animal
      evidence alone, or strong mechanistic evidence alone.
  GROUP_3:
    text: GROUP_3
    description: Group 3 - Not classifiable as to its carcinogenicity to humans. A
      statement that the evidence is inadequate, NOT a finding of safety. Do not report
      a Group 3 agent as non-carcinogenic.
  GROUP_4:
    text: GROUP_4
    description: 'Group 4 - Probably not carcinogenic to humans. **Withdrawn**: the
      category was removed by the January 2019 amendment to the Preamble, having only
      ever been applied to a single agent - caprolactam, which was moved to Group
      3 in the same revision. Retained only so historical assignments citing the pre-2019
      scheme remain resolvable; never use for new curation.'
    deprecated: Removed from the IARC classification scheme by the 2019 Preamble amendment.
      There is no replacement category; an agent formerly in Group 4 is now evaluated
      under the remaining groups.