Enum: ExposureDurationEnum

Duration of exposure. The day ranges given are those used by the US Agency for Toxic Substances and Disease Registry (ATSDR) in deriving Minimal Risk Levels, which is the most precisely specified of the common conventions: acute 1-14 days, intermediate 15-364 days, chronic 365 days and longer.

Beware that agencies do not agree on the bin boundaries — EPA risk assessment uses acute / short-term / subchronic / chronic with different cut points, and the occupational literature often uses "chronic" to mean simply "long-term" with no threshold. The values here carry the ATSDR ranges as their definition; when a source uses a different convention, pick the value whose meaning matches and say so in notes rather than forcing the source's word onto a value with a different range.

This describes the exposure, not the disease course. A single acute exposure can cause a chronic disease; use temporality / clinical_course on the phenotype descriptor for the latter.

URI: dismech:enum/ExposureDurationEnum

Permissible Values

Value	Meaning	Description
ACUTE	None	A single exposure or repeated exposure over 1-14 days (ATSDR acute duration)
INTERMEDIATE	None	Repeated exposure over 15-364 days (ATSDR intermediate duration)
CHRONIC	None	Repeated exposure over 365 days or longer (ATSDR chronic duration)
INTERMITTENT	None	Recurrent discrete exposures separated by exposure-free intervals, where the ...
LIFETIME	None	Continuous exposure across the whole lifespan, the framing used for ubiquitou...
UNKNOWN	None	Duration not established or not reported by the cited source

Slots

Name	Description
classification_value

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: ExposureDurationEnum
description: 'Duration of exposure. The day ranges given are those used by the US
  Agency for Toxic Substances and Disease Registry (ATSDR) in deriving Minimal Risk
  Levels, which is the most precisely specified of the common conventions: acute 1-14
  days, intermediate 15-364 days, chronic 365 days and longer.

  Beware that agencies do not agree on the bin boundaries — EPA risk assessment uses
  acute / short-term / subchronic / chronic with different cut points, and the occupational
  literature often uses "chronic" to mean simply "long-term" with no threshold. The
  values here carry the ATSDR ranges as their definition; when a source uses a different
  convention, pick the value whose *meaning* matches and say so in ``notes`` rather
  than forcing the source''s word onto a value with a different range.

  This describes the exposure, not the disease course. A single acute exposure can
  cause a chronic disease; use ``temporality`` / ``clinical_course`` on the phenotype
  descriptor for the latter.'
from_schema: https://w3id.org/monarch-initiative/dismech
source: https://www.atsdr.cdc.gov/minimal-risk-levels/php/about/index.html
rank: 1000
permissible_values:
  ACUTE:
    text: ACUTE
    description: A single exposure or repeated exposure over 1-14 days (ATSDR acute
      duration). Includes the single high-dose incident, spill or release.
  INTERMEDIATE:
    text: INTERMEDIATE
    description: Repeated exposure over 15-364 days (ATSDR intermediate duration).
      Overlaps what other agencies call subacute or subchronic.
  CHRONIC:
    text: CHRONIC
    description: Repeated exposure over 365 days or longer (ATSDR chronic duration).
      The usual shape of an occupational exposure across a working life.
  INTERMITTENT:
    text: INTERMITTENT
    description: Recurrent discrete exposures separated by exposure-free intervals,
      where the episodic pattern rather than the cumulative dose is the salient feature
      (task-based peak exposure, seasonal work).
  LIFETIME:
    text: LIFETIME
    description: Continuous exposure across the whole lifespan, the framing used for
      ubiquitous environmental agents (background air pollution, residential radon)
      and for lifetime-risk cancer estimates.
  UNKNOWN:
    text: UNKNOWN
    description: Duration not established or not reported by the cited source.