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Enum: ExposomeDomainEnum

Domain of the exposome, following the three-domain framing set out by Christopher Wild ("The exposome: from concept to utility", Int J Epidemiol 2012;41(1):24-32, PMID:22296988), which extended his 2005 proposal of the exposome as the totality of non-genetic exposures from conception onwards.

Wild is explicit that the domains overlap and that some exposures are hard to place — the internal domain is partly a response to the external. Use the value that names where the exposure is measured or acts, and do not treat a placement as a sharp claim. This axis is included because it is the standard vocabulary of exposome-scale epidemiology, which is increasingly the source of the environmental associations dismech curates; it is a framing device, not a regulatory instrument like the other enums here.

URI: dismech:enum/ExposomeDomainEnum

Permissible Values

Value Meaning Description
GENERAL_EXTERNAL None The general external environment - the wider social, economic and built conte...
SPECIFIC_EXTERNAL None The specific external environment - identifiable individual-level exposures: ...
INTERNAL None The internal environment - internal biological processes reflecting and respo...

Slots

Name Description
classification_value

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: ExposomeDomainEnum
description: 'Domain of the exposome, following the three-domain framing set out by
  Christopher Wild ("The exposome: from concept to utility", Int J Epidemiol 2012;41(1):24-32,
  PMID:22296988), which extended his 2005 proposal of the exposome as the totality
  of non-genetic exposures from conception onwards.

  Wild is explicit that the domains overlap and that some exposures are hard to place
  — the internal domain is partly a *response* to the external. Use the value that
  names where the exposure is measured or acts, and do not treat a placement as a
  sharp claim. This axis is included because it is the standard vocabulary of exposome-scale
  epidemiology, which is increasingly the source of the environmental associations
  dismech curates; it is a framing device, not a regulatory instrument like the other
  enums here.'
from_schema: https://w3id.org/monarch-initiative/dismech
source: PMID:22296988
rank: 1000
permissible_values:
  GENERAL_EXTERNAL:
    text: GENERAL_EXTERNAL
    description: 'The general external environment - the wider social, economic and
      built context: socioeconomic position, education, urban-rural setting, climate,
      and other exposures acting at population rather than individual scale.'
  SPECIFIC_EXTERNAL:
    text: SPECIFIC_EXTERNAL
    description: 'The specific external environment - identifiable individual-level
      exposures: chemical contaminants, occupational agents, radiation, infections,
      diet, tobacco, alcohol, physical activity.'
  INTERNAL:
    text: INTERNAL
    description: 'The internal environment - internal biological processes reflecting
      and responding to exposure: metabolism, endogenous hormones, oxidative stress,
      inflammation, gut microbiome, epigenetic modification.'