Enum: EnvironmentalEffectEnum

How an environmental factor or exposure acts on its subject. The environmental analogue of TreatmentEffectEnum, used to keep causative, aggravating, and protective exposures visually and semantically distinct in the pathograph.

URI: dismech:enum/EnvironmentalEffectEnum

Permissible Values

Value	Meaning	Description	Additional Info
TRIGGERS	None	The exposure initiates the mechanism or disease, which would not otherwise oc...	Title: Triggers
EXACERBATES	None	The exposure worsens or amplifies a mechanism or disease that is already pres...	Title: Exacerbates
PREDISPOSES	None	The exposure increases susceptibility to the mechanism or disease without bei...	Title: Predisposes
PROTECTS_AGAINST	None	The exposure reduces the occurrence or severity of the mechanism or disease (...	Title: Protects against
MODULATES	None	The exposure alters the mechanism or disease without a clear unidirectional e...	Title: Modulates

Slots

Name	Description
disease_effect	How this exposure acts on the disease as a whole, as opposed to on any one me...
environmental_effect	How the environmental factor affects the targeted mechanism

Comments

• Used at two scopes, and the value means the same thing at both. On EnvironmentalMechanismTarget.environmental_effect the subject is one pathophysiology or phenotype node; on Environmental.disease_effect it is the disease as a whole. An exposure may legitimately carry a different value at each scope -- one that PROTECTS_AGAINST a mechanism while it PREDISPOSES to the disease is a real pattern, not a contradiction.
• Direction only. How strongly the exposure determines the outcome is Environmental.causal_role, a separate axis.

Identifier and Mapping Information

Schema Source

• from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: EnvironmentalEffectEnum
description: How an environmental factor or exposure acts on its subject. The environmental
  analogue of TreatmentEffectEnum, used to keep causative, aggravating, and protective
  exposures visually and semantically distinct in the pathograph.
comments:
- Used at two scopes, and the value means the same thing at both. On EnvironmentalMechanismTarget.environmental_effect
  the subject is one pathophysiology or phenotype node; on Environmental.disease_effect
  it is the disease as a whole. An exposure may legitimately carry a different value
  at each scope -- one that PROTECTS_AGAINST a mechanism while it PREDISPOSES to the
  disease is a real pattern, not a contradiction.
- Direction only. How strongly the exposure determines the outcome is Environmental.causal_role,
  a separate axis.
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  TRIGGERS:
    text: TRIGGERS
    description: The exposure initiates the mechanism or disease, which would not
      otherwise occur in its absence (e.g., inorganic arsenic ingestion initiating
      systemic arsenic exposure; allergen contact initiating sensitization; gluten
      ingestion initiating coeliac enteropathy).
    title: Triggers
  EXACERBATES:
    text: EXACERBATES
    description: The exposure worsens or amplifies a mechanism or disease that is
      already present or can arise independently (e.g., tobacco smoke amplifying airway
      inflammation).
    title: Exacerbates
  PREDISPOSES:
    text: PREDISPOSES
    description: The exposure increases susceptibility to the mechanism or disease
      without being sufficient to produce it (e.g., a risk-factor exposure that requires
      additional genetic or environmental hits).
    title: Predisposes
  PROTECTS_AGAINST:
    text: PROTECTS_AGAINST
    description: The exposure reduces the occurrence or severity of the mechanism
      or disease (e.g., early-life microbial exposure and allergic sensitization).
    title: Protects against
  MODULATES:
    text: MODULATES
    description: The exposure alters the mechanism or disease without a clear unidirectional
      effect, or the direction is context dependent.
    title: Modulates