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Enum: EnvironmentalEffectEnum

How an environmental factor or exposure acts on a pathophysiology mechanism node. The environmental analogue of TreatmentEffectEnum, used to keep causative, aggravating, and protective exposures visually and semantically distinct in the pathograph.

URI: dismech:enum/EnvironmentalEffectEnum

Permissible Values

Value Meaning Description Additional Info
TRIGGERS None The exposure initiates the mechanism, which would not otherwise occur in its ... Title: Triggers
EXACERBATES None The exposure worsens or amplifies a mechanism that is already present or can ... Title: Exacerbates
PREDISPOSES None The exposure increases susceptibility to the mechanism without being sufficie... Title: Predisposes
PROTECTS_AGAINST None The exposure reduces the occurrence or severity of the mechanism (e Title: Protects against
MODULATES None The exposure alters the mechanism without a clear unidirectional effect, or t... Title: Modulates

Slots

Name Description
environmental_effect How the environmental factor affects the targeted mechanism

Identifier and Mapping Information

Schema Source

  • from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: EnvironmentalEffectEnum
description: How an environmental factor or exposure acts on a pathophysiology mechanism
  node. The environmental analogue of TreatmentEffectEnum, used to keep causative,
  aggravating, and protective exposures visually and semantically distinct in the
  pathograph.
from_schema: https://w3id.org/monarch-initiative/dismech
rank: 1000
permissible_values:
  TRIGGERS:
    text: TRIGGERS
    description: The exposure initiates the mechanism, which would not otherwise occur
      in its absence (e.g., inorganic arsenic ingestion initiating systemic arsenic
      exposure; allergen contact initiating sensitization).
    title: Triggers
  EXACERBATES:
    text: EXACERBATES
    description: The exposure worsens or amplifies a mechanism that is already present
      or can arise independently (e.g., tobacco smoke amplifying airway inflammation).
    title: Exacerbates
  PREDISPOSES:
    text: PREDISPOSES
    description: The exposure increases susceptibility to the mechanism without being
      sufficient to produce it (e.g., a risk-factor exposure that requires additional
      genetic or environmental hits).
    title: Predisposes
  PROTECTS_AGAINST:
    text: PROTECTS_AGAINST
    description: The exposure reduces the occurrence or severity of the mechanism
      (e.g., early-life microbial exposure and allergic sensitization).
    title: Protects against
  MODULATES:
    text: MODULATES
    description: The exposure alters the mechanism without a clear unidirectional
      effect, or the direction is context dependent.
    title: Modulates