Enum: DeliveryPlatformEnum

How a treatment's active agent is carried to its target tissue. This is the delivery strategy, not the targeting ligand (see targeting_ligand) and not the route of administration: it is what solves the stability, cellular-uptake, and endosomal-escape problem for a given drug. The distinction is clinically load-bearing - patisiran and vutrisiran silence the same transcript, but the lipid-nanoparticle formulation is dosed intravenously every three weeks with premedication, while the GalNAc conjugate is dosed subcutaneously every three months without it. The same axis separates two formulations of one small molecule: conventional and albumin-bound paclitaxel share an agent and differ in carrier.

URI: dismech:enum/DeliveryPlatformEnum

Permissible Values

Value	Meaning	Description	Additional Info
UNFORMULATED	None	Chemically stabilized oligonucleotide administered without a carrier or targe...	Title: Unformulated / free uptake
CONJUGATE	None	Covalently conjugated to a targeting ligand that drives receptor-mediated upt...	Title: Ligand conjugate
LIPID_NANOPARTICLE	None	Encapsulated in an ionizable-lipid nanoparticle that protects the payload and...	Title: Lipid nanoparticle (LNP)
LIPOSOME	None	Encapsulated in a phospholipid bilayer vesicle, commonly PEGylated for circul...	Title: Liposome
POLYMER_NANOPARTICLE	None	Encapsulated in a polymeric or dendrimer nanoparticle
PROTEIN_NANOPARTICLE	None	Bound to or assembled with a carrier protein, usually albumin, to solubilize ...	Title: Protein nanoparticle (albumin-bound)
INORGANIC_NANOPARTICLE	None	Carried on an inorganic core such as iron oxide, gold, or hafnium oxide
VIRAL_VECTOR	None	Delivered by an engineered viral vector (e
EXOSOME	None	Delivered in an exosome or other extracellular vesicle	Title: Exosome / extracellular vesicle
OTHER	None	Delivery platform not covered by the above categories

Slots

Name	Description
delivery_platform	How the active agent is carried to its target tissue - unformulated, ligand c...

Aliases

OligonucleotideDeliveryPlatformEnum

Identifier and Mapping Information

Schema Source

from schema: https://w3id.org/monarch-initiative/dismech

LinkML Source

name: DeliveryPlatformEnum
description: 'How a treatment''s active agent is carried to its target tissue. This
  is the delivery strategy, not the targeting ligand (see targeting_ligand) and not
  the route of administration: it is what solves the stability, cellular-uptake, and
  endosomal-escape problem for a given drug. The distinction is clinically load-bearing
  - patisiran and vutrisiran silence the same transcript, but the lipid-nanoparticle
  formulation is dosed intravenously every three weeks with premedication, while the
  GalNAc conjugate is dosed subcutaneously every three months without it. The same
  axis separates two formulations of one small molecule: conventional and albumin-bound
  paclitaxel share an agent and differ in carrier.'
from_schema: https://w3id.org/monarch-initiative/dismech
aliases:
- OligonucleotideDeliveryPlatformEnum
rank: 1000
permissible_values:
  UNFORMULATED:
    text: UNFORMULATED
    description: Chemically stabilized oligonucleotide administered without a carrier
      or targeting ligand, relying on free tissue uptake (e.g., intrathecal nusinersen,
      subcutaneous inotersen)
    title: Unformulated / free uptake
  CONJUGATE:
    text: CONJUGATE
    description: Covalently conjugated to a targeting ligand that drives receptor-mediated
      uptake; the specific ligand is recorded in targeting_ligand (e.g., GalNAc for
      hepatocyte ASGR1 uptake)
    title: Ligand conjugate
  LIPID_NANOPARTICLE:
    text: LIPID_NANOPARTICLE
    description: Encapsulated in an ionizable-lipid nanoparticle that protects the
      payload and destabilizes the endosomal membrane on acidification (e.g., patisiran,
      mRNA therapeutics). Distinct from LIPOSOME - the ionizable lipid is what releases
      a nucleic-acid payload from the endosome
    title: Lipid nanoparticle (LNP)
  LIPOSOME:
    text: LIPOSOME
    description: Encapsulated in a phospholipid bilayer vesicle, commonly PEGylated
      for circulation time, altering biodistribution and toxicity of an already cell-permeant
      agent rather than solving endosomal escape (e.g., liposomal doxorubicin, liposomal
      irinotecan, liposomal amphotericin B)
    title: Liposome
  POLYMER_NANOPARTICLE:
    text: POLYMER_NANOPARTICLE
    description: Encapsulated in a polymeric or dendrimer nanoparticle
  PROTEIN_NANOPARTICLE:
    text: PROTEIN_NANOPARTICLE
    description: Bound to or assembled with a carrier protein, usually albumin, to
      solubilize a hydrophobic agent without a synthetic surfactant (e.g., nab-paclitaxel,
      nab-sirolimus)
    title: Protein nanoparticle (albumin-bound)
  INORGANIC_NANOPARTICLE:
    text: INORGANIC_NANOPARTICLE
    description: Carried on an inorganic core such as iron oxide, gold, or hafnium
      oxide
  VIRAL_VECTOR:
    text: VIRAL_VECTOR
    description: Delivered by an engineered viral vector (e.g., AAV-expressed short
      hairpin RNA)
  EXOSOME:
    text: EXOSOME
    description: Delivered in an exosome or other extracellular vesicle
    title: Exosome / extracellular vesicle
  OTHER:
    text: OTHER
    description: Delivery platform not covered by the above categories