Harrison's Principles of Internal Medicine Part Classification
Part-level classification for organizing disorders by organ system and clinical domain, following the high-level structure of Harrison's Principles of Internal Medicine.
Harrison's Principles of Internal Medicine classification by Part. Values correspond to the high-level Parts (organ-system or topical groupings) of Harrison's 21st edition (2022). The slot is named `harrisons_chapter` for historical reasons, but the controlled vocabulary lives at the Part level since this is the granularity that matches how curators classify disorders. A single disease may be assigned to multiple Parts (e.g., a hereditary skin disorder could be tagged DERMATOLOGY and GENETICS_ENVIRONMENT_DISEASE). Free-text values used in earlier curation are preserved as `aliases` on the closest-fit Part so that legacy entries continue to validate.
General Considerations in Clinical MedicineGENERAL_CONSIDERATIONS
Approach to the patient, clinical decision-making, ethics, evidence-based medicine, screening, and global aspects of medicine. Use sparingly for diseases - most diseases fit a more specific organ-system Part.
Cardinal Manifestations and Presentation of DiseasesCARDINAL_MANIFESTATIONS
Cardinal symptom and sign presentations (pain, fever, fatigue, weight change, cough, dyspnea, etc.) and chapters on alterations of the skin, ear, nose, and throat. Use for symptom-defined entries that cut across organ systems.
PharmacologyPHARMACOLOGY
Principles of clinical pharmacology, drug therapeutics, and adverse drug reactions. Rarely used for disorder entries.
Oncology and HematologyONCOLOGY_HEMATOLOGY
Cancers (solid tumors and hematologic malignancies) and non-malignant hematologic disorders including anemias, coagulation disorders, transfusion medicine, and bone marrow failure syndromes.
Bacterial, viral, fungal, parasitic, and other microbial infections; antimicrobial therapy; infections in immunocompromised hosts; and infections by organ system when presented from an infectious-disease perspective.
Disorders of the Cardiovascular SystemCARDIOVASCULAR
Cardiac and vascular diseases including ischemic heart disease, heart failure, arrhythmias, cardiomyopathies, valvular and pericardial disease, congenital heart disease, and disorders of the aorta and peripheral vasculature.
Approach to the critically ill patient, including sepsis and septic shock, ARDS, multi-organ failure, and neurologic critical illness.
Disorders of the Kidney and Urinary TractKIDNEY_URINARY_TRACT
Renal and urinary tract diseases including glomerular and tubulointerstitial disorders, acute kidney injury, chronic kidney disease, electrolyte and acid-base disturbances, and urolithiasis.
Immune-Mediated, Inflammatory, and Rheumatologic DisordersIMMUNE_RHEUMATOLOGIC
Autoimmune and immune-mediated conditions, connective-tissue diseases, vasculitides, and rheumatologic disorders. Musculoskeletal disorders are also covered here in Harrison's.
Endocrinology and MetabolismENDOCRINOLOGY_METABOLISM
Endocrine and metabolic diseases including diabetes mellitus, thyroid, adrenal, pituitary, gonadal, calcium and bone metabolism, lipid disorders, and inborn errors of metabolism.
Diseases of the central and peripheral nervous system, including stroke, epilepsy, neurodegenerative disease, movement disorders, demyelinating disease, neuromuscular disease, headache, and psychiatric disorders.
Skin and cutaneous disorders. In Harrison's 21st edition, dermatology is organized as a section within the cardinal manifestations Part; this enum value is provided separately so that disorders that are primarily dermatologic can be classified directly.
Disorders Associated with Environmental ExposuresENVIRONMENTAL_EXPOSURES
Disorders attributable to environmental exposures such as altitude, hypothermia/hyperthermia, drowning, and radiation injury.
Genes, the Environment, and DiseaseGENETICS_ENVIRONMENT_DISEASE
Genetic and genomic medicine, chromosomal and Mendelian disorders not better classified by organ system, and the interplay of genes and environment in disease. Use for mechanism-defined entries (RASopathies, ciliopathies, mitochondrial disease, etc.) that span multiple organ systems.