Aliases: N-ras.
ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Ameloblastoma | somatic driver somatic |
mechanism: Somatic RTK-RAS-MAPK Driver Alterations
|
| Anal Canal Adenocarcinoma | biomarker somatic | |
| Embryonal Rhabdomyosarcoma | somatic driver somatic |
mechanism: RAS Pathway Activation
|
| Medullary Thyroid Carcinoma | somatic driver somatic |
mechanism: RAS Mutation-Driven Proliferation
scoped to subtype: Sporadic MTC
|
| Noonan Syndrome 6 | causative |
mechanism: NRAS Germline Gain-of-Function Variant; Oncogenic-Codon Germline Alleles and Tumor Predisposition
discussion: (unnamed)
|
| Ocular Melanoma | somatic driver somatic |
mechanism: UV-Associated BRAF/NRAS/NF1 Driver Activation
subtype: Conjunctival Melanoma
scoped to subtype: Conjunctival Melanoma
|
| Rosai-Dorfman Disease | somatic driver somatic | |
| Systemic Mastocytosis | cooperating somatic | |
| Thyroid Follicular Carcinoma | somatic driver somatic |
mechanism: RAS and PAX8-PPARG Driver Alterations
|
| Cardiofaciocutaneous Syndrome |
untyped
Pathogenic Variants
|
|
| Central Nervous System Germ Cell Tumor |
untyped
Recurrent somatic KIT-RAS-pathway mutation
somatic
|
mechanism: Recurrent KIT-RAS Signaling Alterations
|
| Costello Syndrome |
untyped
Pathogenic Variants
|
|
| Cutaneous Melanoma |
untyped
Somatic activating mutation
|
|
| Juvenile Myelomonocytic Leukemia |
untyped
Somatic activating mutation
|
scoped to subtype: NRAS-mutated
|
| Melanoma_in_Congenital_Melanocytic_Nevus |
untyped
Mutations
somatic
|
mechanism: Genetic Mutations
|
| Noonan Syndrome |
untyped
Pathogenic Variants
|
mechanism: Additional RAS-MAPK Signal-Amplifying Variants
subtype: NS6
scoped to subtype: NS6
|
| NRAS Mutant Melanoma |
untyped
Somatic Oncogenic Mutation
|
|
| Pleuropulmonary Blastoma |
untyped
Occasional Somatic Activating Mutation
|
mechanism: RAS Pathway Activation
|
| BRAF V600E-Mutant Non-Small Cell Lung Cancer | no genetic record |
mechanism: MAPK Reactivation and Bypass Resistance
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| Noonan syndrome with multiple lentigines MONDO:0007893 | AD | Limited 2018-05-30 |
Noonan Syndrome
untyped
Noonan Syndrome with Multiple Lentigines
not named
|
| Costello syndrome MONDO:0009026 | AD | Limited 2018-07-24 |
Costello Syndrome
untyped
|
| cardiofaciocutaneous syndrome MONDO:0015280 | AD | Limited 2018-07-24 |
Cardiofaciocutaneous Syndrome
untyped
|
| Noonan syndrome MONDO:0018997 | AD | Definitive 2018-05-30 |
Noonan Syndrome
untyped
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.