Aliases: Raf-1, c-Raf, CRAF.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Dilated Cardiomyopathy 1NN | causative |
mechanism: RAF1 Variant Altering Kinase Activity
|
| Pilocytic Astrocytoma | somatic driver somatic |
mechanism: Constitutive MAPK Cascade Activation
|
| Melanoma_in_Congenital_Melanocytic_Nevus |
untyped
Gene fusions
|
|
| Noonan Syndrome |
untyped
Pathogenic Variants
|
mechanism: RAF1 Kinase Hyperactivation
subtype: NS5
scoped to subtype: NS5
|
| Noonan Syndrome with Multiple Lentigines |
untyped
Pathogenic Variants
|
mechanism: RAF1/BRAF Kinase Gain-of-Function
subtype: LPRD2
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| Noonan syndrome with multiple lentigines MONDO:0007893 | AD | Limited 2018-07-25 |
Noonan Syndrome
untyped
|
| Costello syndrome MONDO:0009026 | AD | Disputed 2018-07-24 |
Costello Syndrome
not named
|
| cardiofaciocutaneous syndrome MONDO:0015280 | AD | Disputed 2018-05-31 |
Cardiofaciocutaneous Syndrome
not named
|
| Noonan syndrome MONDO:0018997 | AD | Definitive 2024-10-23 |
Noonan Syndrome
untyped
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.