Previous symbols: PTPN8. Aliases: Lyp, Lyp1, Lyp2.
ai-gene-review has this gene at status IN_PROGRESS; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Adult-Onset Myasthenia Gravis | susceptibility | |
| Autoimmune Polyendocrinopathy | risk factor germline |
mechanism: Polygenic HLA and Immune-Regulatory Susceptibility
scoped to subtype: Type 2
|
| Celiac Disease | susceptibility | |
| Hashimoto's Thyroiditis | susceptibility |
mechanism: Loss of Immune Tolerance to Thyroid Antigens
|
| Type I Diabetes | susceptibility germline | |
| Addison's Disease |
untyped
Tyrosine phosphatase modulating T-cell receptor signaling
|
mechanism: Polygenic Susceptibility
|
| Ankylosing Spondylitis |
untyped
GWAS
|
|
| Crohn Disease |
untyped
GWAS
|
|
| Diabetes mellitus |
untyped
Susceptibility
|
scoped to subtype: type 1 diabetes mellitus
|
| Giant Cell Arteritis |
untyped
Risk Factor
|
|
| Granulomatosis with Polyangiitis |
untyped
Risk Factor
|
|
| Graves' Disease |
untyped
Risk Factor
|
|
| Multiple Sclerosis |
untyped
GWAS
|
|
| Psoriasis |
untyped
GWAS
|
|
| Rheumatoid Arthritis |
untyped
Associated with increased risk
|
mechanism: Autoimmune Response
|
| Systemic Lupus Erythematosus |
untyped
Associated
|
|
| Ulcerative Colitis |
untyped
GWAS
|
|
| Vitiligo |
untyped
Associated
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.