Previous symbols: HLA-DR1B.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Acquired Epidermolysis Bullosa | susceptibility |
mechanism: HLA-Associated Susceptibility to COL7 Autoimmunity
|
| Adult-Onset Myasthenia Gravis | susceptibility | |
| Alopecia Areata | susceptibility germline |
mechanism: Follicular Antigen and NKG2D-Ligand Display; Loss of Hair Follicle Immune Privilege
|
| Anti-Glomerular Basement Membrane Disease | risk factor |
mechanism: HLA-restricted loss of tolerance and anti-GBM IgG production
|
| Antisynthetase Syndrome | susceptibility |
mechanism: Loss of Tolerance to Aminoacyl-tRNA Synthetases
|
| Autoimmune Hepatitis | risk factor germline |
mechanism: Polygenic HLA-linked susceptibility
|
| Autoimmune Pancreatitis | susceptibility |
scoped to subtype: Type 1
|
| Autoimmune Polyendocrinopathy | risk factor germline |
mechanism: Polygenic HLA and Immune-Regulatory Susceptibility
scoped to subtype: Type 2
|
| Autoimmune Pulmonary Alveolar Proteinosis | susceptibility germline |
mechanism: Loss of Immune Tolerance to GM-CSF
|
| Eosinophilia-Myalgia Syndrome | risk factor | |
| Genital Lichen Sclerosus | susceptibility |
scoped to subtype: Vulvar Lichen Sclerosus
|
| IgG4-Related Disease | risk factor | |
| Inclusion Body Myositis | susceptibility | |
| Minimal Change Disease | susceptibility | |
| Mucous Membrane Pemphigoid | susceptibility | |
| Neurosarcoidosis | modifier germline | |
| Paraneoplastic Cerebellar Degeneration | susceptibility | |
| Pemphigus Foliaceus | susceptibility |
mechanism: HLA-DRB1-Restricted Susceptibility
|
| Polymyalgia Rheumatica | modifier | |
| Primary Biliary Cholangitis | susceptibility | |
| Primary Sclerosing Cholangitis | susceptibility | |
| Relapsing Polychondritis | risk factor germline | |
| Rheumatic Heart Disease | susceptibility germline | |
| Rosacea | susceptibility | |
| Toxic Oil Syndrome | modifier | |
| Toxic Shock Syndrome | susceptibility | |
| Vogt-Koyanagi-Harada Disease | risk factor germline |
mechanism: HLA-DRB1-Restricted Melanocyte Antigen Recognition
|
| Giant Cell Arteritis |
untyped
Risk Factor
|
|
| Graves' Disease |
untyped
Risk Factor
|
|
| Juvenile Idiopathic Arthritis |
untyped
Susceptibility
|
|
| Multiple Sclerosis |
untyped
Risk Factor
|
mechanism: Th1/Th17-Mediated Neuroinflammation
|
| Rheumatoid Arthritis |
untyped
Associated with increased risk
|
mechanism: Autoimmune Response
|
| Sarcoidosis |
untyped
Susceptibility
|
|
| Systemic Sclerosis |
untyped
Risk Factor
|
|
| Ulcerative Colitis |
untyped
Risk Factor
|
mechanism: Dysregulated Immune Response
|
| Vitiligo |
untyped
Associated
|
|
| Addison's Disease | no genetic record |
mechanism: Polygenic Susceptibility
|
| Podoconiosis | no genetic record |
mechanism: HLA Class II-Restricted CD4 T-Cell Response
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.