Disorder
- Name: Noonan Syndrome
- Category: Genetic
- Existing deep-research providers: falcon
- Existing evidence reference count in YAML: 31
Key Pathophysiology Nodes
- SHP2 Gain-of-Function Activation
- SOS1-Mediated RAS-GTP Loading
- RAF1 Kinase Hyperactivation
- RIT1-Mediated RAF Recruitment
- LZTR1-Mediated RAS Proteostasis Defect
- ERK Cascade Hyperactivation
- Cardiac Valve Morphogenesis Defects
- Cardiomyocyte Hypertrophy
- Deep research literature mapping
Citation Inventory (for evidence mapping)