Dupuytren Contracture (Dupuytren disease) — Disease Characteristics Research Report

Executive overview

Dupuytren contracture is a chronic fibroproliferative/fibrotic disorder of the palmar fascia (palmar aponeurosis) that forms palmar nodules and cords and can progress to fixed flexion contractures, classically affecting the ring and little fingers and impairing hand function. (khaliq2024dupuytrenscontracturea pages 1-2)

Recent high-impact genetic studies (2023–2024) reinforce that Dupuytren disease is highly heritable and polygenic, with risk loci converging on fibroblast/myofibroblast biology and pro-fibrotic signaling (e.g., TGF-β; developmental pathways Hedgehog/Notch; cell–matrix adhesion). (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4)

Clinically, minimally invasive treatments (collagenase clostridium histolyticum injection and percutaneous needle aponeurotomy/fasciotomy) are widely used, especially for earlier disease, but recurrence is common; surgery (limited fasciectomy/dermofasciectomy) remains standard for advanced contracture. (khaliq2024dupuytrenscontracturea pages 4-5, khaliq2024dupuytrenscontracturea pages 5-6)

1. Disease information

Definition and current understanding

Dupuytren’s contracture is described as a “chronic fibroproliferative disease of the palmar fascia” causing progressive flexion deformities via development of fibrotic cords. (khaliq2024dupuytrenscontracturea pages 1-2)

Key identifiers and nomenclature

Table: This table summarizes the core identifiers and naming conventions for Dupuytren contracture/disease from the retrieved evidence. It also flags that MONDO, Orphanet, and OMIM identifiers were not present in the available context and would need dedicated ontology lookup.

Notes/limitations: MONDO, Orphanet, and OMIM identifiers were not present in the retrieved full-text evidence for this run; adding these would require dedicated ontology lookup beyond the current context. (NCT06321991 chunk 2, khaliq2024dupuytrenscontracturea pages 4-5)

Disease information source type

Evidence in this report comes from aggregated resources: peer-reviewed reviews/meta-analyses and large biobank GWAS/meta-analyses; administrative coding studies (England HES) are also used for utilization/costs. (gerber2011dupuytrenscontracturea pages 1-2, riesmeijer2024agenomewideassociation pages 1-2)

2. Etiology

Disease causal factors (multifactorial)

Dupuytren disease is multifactorial with strong genetic predisposition plus environmental/occupational and lifestyle contributions. A 2024 meta-GWAS frames the disorder as heritable and fibrotic, and also cites established non-genetic risk factors (age, male sex, smoking, alcohol, manual work). (riesmeijer2024agenomewideassociation pages 1-2)

Risk factors (genetic)

2024 large meta-GWAS (primary): - Design: 11,320 cases, 47,023 controls; 8,123,121 variants. (riesmeijer2024agenomewideassociation pages 1-2) - Findings: 85 genome-wide significant SNPs in 56 loci (11 novel); 24 additional secondary signals in 12 known loci; loci/PRS explain 13.3–38.1% of disease variance (cohort-dependent). (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4) - Genetic correlations: frozen shoulder r=0.30 (p=1.9×10−6); BMI r=−0.14 (p=1.2×10−8); HDL r=0.12 (p=3.6×10−5). (riesmeijer2024agenomewideassociation pages 2-4)

2023 biobank meta-analysis (Neandertal-derived risk factors): - Design: 7,871 cases, 645,880 controls. (agren2023majorgeneticrisk pages 1-2) - Findings: 61 genome-wide significant loci; 3 loci harbor Neandertal-derived risk alleles; carrying all 3 Neandertal risk alleles OR=2.83 (95% CI 2.62–3.05). (agren2023majorgeneticrisk pages 2-3)

ECM gene polymorphisms (case-control, Lithuania): - CHST6 rs977987 minor T allele associated with risk (~1.404-fold per minor allele; TT genotype ~1.7× more likely). (samulenas2022theroleof pages 7-8) - MMP14 rs1042704 AA genotype associated with earlier onset and ~2.16-fold increased odds. (samulenas2022theroleof pages 7-8)

Risk factors (environmental/lifestyle/occupational)

• Smoking and manual labor are repeatedly cited as risk factors, and quantified effects were reported in Samulėnas et al.: smoking ~2.084× risk; manual labor ~2.6× risk. (samulenas2022theroleof pages 7-8, samulenas2022theroleof pages 1-2)
• A gene–environment interaction signal was reported: smoking + manual labor increased incidence 13.2-fold vs neither exposure; adding the MMP14 minor A allele increased likelihood to ~14-fold. (samulenas2022theroleof pages 7-8, samulenas2022theroleof pages 1-2)

Protective factors

Genetic analyses suggest adiposity is “causally protective” and show negative genetic correlation with BMI. (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4)

Gene–environment interactions

A specific GxE interaction was quantified with MMP14 rs1042704 and smoking/manual labor exposures (above), providing direct evidence that inherited susceptibility can amplify occupational/lifestyle risks. (samulenas2022theroleof pages 7-8, samulenas2022theroleof pages 1-2)

3. Phenotypes

Core phenotypes and characteristics

• Palmar nodules and palmar cords in palmar fascia/aponeurosis progressing to finger flexion contracture / reduced extension (often painless but function-limiting). (khaliq2024dupuytrenscontracturea pages 1-2, khaliq2024dupuytrenscontracturea pages 4-5)
• Predominant involvement of ring (4th) and small (5th) digits; MCP and PIP joints are frequently involved. (khaliq2024dupuytrenscontracturea pages 1-2, alhebshi2024comparingcomplicationsand pages 1-2)
• Spiral cords can cause PIP contractures and can displace the neurovascular bundle; natatory cords can affect web spaces. (khaliq2024dupuytrenscontracturea pages 2-4, khaliq2024dupuytrenscontracturea pages 1-2)

Staging / severity

Tubiana / TPED staging (total extension deficit across MCP+PIP+DIP): - Stage I: 0–45° - Stage II: 45–90° - Stage III: 90–135° - Stage IV: >135° Also includes Stage N (nodule without contracture). (khaliq2024dupuytrenscontracturea pages 4-5)

Quality of life impact

PROMs used to quantify patient-perceived function/impact include DASH, Michigan Hand Outcomes Questionnaire, and Patient Evaluation Measure; advanced-disease percutaneous treatment series used quickDASH and URAM. (khaliq2024dupuytrenscontracturea pages 4-5, basile2024challengesandinnovations pages 1-2)

Suggested HPO terms (examples)

(Provided as ontology suggestions; exact IDs not retrieved in current context) - Palmar nodule - Palmar fibromatosis / palmar cord - Finger flexion contracture - Decreased range of motion of finger joints (MCP/PIP/DIP) - Hand function impairment - Skin dimpling of palm (as described clinically) (khaliq2024dupuytrenscontracturea pages 2-4, khaliq2024dupuytrenscontracturea pages 4-5)

4. Genetic / molecular information

Causal genes vs susceptibility architecture

Dupuytren disease is best supported as a polygenic complex trait rather than a single-gene Mendelian disorder, with dozens of loci and substantial variance explained by common variants in large GWAS. (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4)

Notable genes/variants highlighted in recent studies

• EPDR1 implicated as a causal gene for a strong Neandertal-derived risk factor, with splicing association in muscle/adipose/fibroblasts. (agren2023majorgeneticrisk pages 2-3)
• Meta-GWAS coding variants included nonsynonymous SNPs mapping to TMEM81, DSTYK, SUMO4, CFTR, TNC, MMP14, and LDHAL6B; multiple analyses highlighted TNC, AFAP1, CHSY1, NEDD4, CFDP1. (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4)

Epigenetics / chromosomal abnormalities

The available evidence did not provide extractable epigenetic profiling or population-scale chromosomal abnormality rates. A 2024 genetics review excerpt referenced cytogenetic findings (e.g., trisomy 7/8, loss of Y) but without study-level quantitative support in the retrieved chunk. (aissvarya2024moleculargeneticsof pages 1-2)

5. Environmental information

Environmental and occupational factors

Manual work exposures and hand-transmitted vibration are discussed in occupational-health oriented sources; the extracted evidence supports risk elevation for vibration-exposed workers (approximately doubled risk in summarized meta-analytic statements), though this run did not retrieve the underlying primary study effect estimates. (nilssonUnknownyeardupuytrenssjukdomi pages 35-38)

Lifestyle factors

Smoking and alcohol are repeatedly cited as associated factors; smoking has quantified effect sizes in Samulėnas et al. (samulenas2022theroleof pages 7-8, riesmeijer2024agenomewideassociation pages 1-2)

Infectious agents

No infectious etiology evidence was found; Dupuytren disease is not presented as an infectious disorder in the retrieved sources. (khaliq2024dupuytrenscontracturea pages 1-2)

6. Mechanism / pathophysiology

Mechanistic causal chain (current understanding)

A consistent chain across recent reviews: 1) Proliferative phase: fibroblast proliferation and nodule formation. (khaliq2024dupuytrenscontracturea pages 2-4) 2) Myofibroblast differentiation with production of extracellular matrix, “particularly type III collagen,” leading to cord formation. (khaliq2024dupuytrenscontracturea pages 2-4) 3) Involutional phase: myofibroblasts align along stress lines, contract, and shorten cords, producing progressive flexion deformity. (khaliq2024dupuytrenscontracturea pages 2-4, alhebshi2024comparingcomplicationsand pages 1-2) 4) Residual phase: cords become relatively acellular but remain thickened/contracted, yielding fixed contracture. (khaliq2024dupuytrenscontracturea pages 2-4, alhebshi2024comparingcomplicationsand pages 1-2)

Key pathways and mediators

• TGF-β is highlighted as a central profibrotic mediator stimulating fibroblast proliferation, myofibroblast differentiation, and collagen production. (khaliq2024dupuytrenscontracturea pages 2-4)
• Inflammatory cytokines (TNF, IL-6) and immune cells (macrophages) are implicated; immune cells secrete profibrotic cytokines and TNF can increase contraction of Dupuytren fibroblasts. (gelbard2021fibroproliferativedisordersand pages 5-6)
• WNT/β-catenin dysregulation is supported by transcriptomic/biochemical evidence in nodules (e.g., WNT7b up, nuclear β-catenin staining); cross-talk between inflammatory mediators and WNT signaling is suggested. (gelbard2021fibroproliferativedisordersand pages 4-5)
• Hedgehog and Notch signaling were implicated by 2024 meta-GWAS gene prioritization; enrichment also implicated TGF-β signaling, epithelial cell migration, and cell–matrix adhesion. (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4)

Cell types (with CL suggestions)

Evidence consistently highlights fibroblasts and myofibroblasts as central effector populations, with cell-type prioritization/association in genetics and mechanistic reviews. (riesmeijer2024agenomewideassociation pages 2-4, alhebshi2024comparingcomplicationsand pages 1-2) - Suggested Cell Ontology terms: fibroblast; myofibroblast; macrophage (as implicated immune correlate). (gelbard2021fibroproliferativedisordersand pages 5-6, riesmeijer2024agenomewideassociation pages 2-4)

GO biological process suggestions (examples)

• Extracellular matrix organization
• Collagen fibril organization
• Fibroblast proliferation
• Myofibroblast differentiation
• Wnt signaling pathway
• Response to transforming growth factor beta
• Cell–matrix adhesion
• Epithelial cell migration (as GWAS-enriched pathway) (khaliq2024dupuytrenscontracturea pages 2-4, riesmeijer2024agenomewideassociation pages 2-4)

7. Anatomical structures affected

Primary anatomical sites

• Palmar fascia/palmar aponeurosis (hand), with cord formation from fascial structures such as pretendinous bands; spiral cords can affect PIP joints and neurovascular bundle position. (khaliq2024dupuytrenscontracturea pages 1-2, khaliq2024dupuytrenscontracturea pages 2-4)

UBERON suggestions (examples; IDs not retrieved in current context): palmar fascia; hand; finger; metacarpophalangeal joint; proximal interphalangeal joint; distal interphalangeal joint. (khaliq2024dupuytrenscontracturea pages 4-5, khaliq2024dupuytrenscontracturea pages 1-2)

8. Temporal development

Onset

Typical onset is after age 40; prevalence increases with age and may reach ~20% in men over 60 in high-prevalence populations. (khaliq2024dupuytrenscontracturea pages 1-2)

Progression

Progression is often insidious and variable; young age at onset and strong family history are associated with more aggressive disease and higher recurrence after treatment. (khaliq2024dupuytrenscontracturea pages 1-2)

9. Inheritance and population

Epidemiology and demographics

Table: This table summarizes high-value evidence on Dupuytren disease epidemiology, healthcare burden, genetic architecture, environmental risk factors, and prognosis. It is useful as a compact evidence map with quantitative findings, study design context, and citation-ready source links.

Key statistics: - European ancestry prevalence ~3–6% overall; up to ~20% in men >60 in some reports. (khaliq2024dupuytrenscontracturea pages 1-2) - Biobank meta-analysis found higher prevalence in European vs African ancestry (e.g., MVP 0.73% vs 0.13%). (agren2023majorgeneticrisk pages 1-2)

Inheritance pattern

The evidence supports a complex/polygenic inheritance pattern with high heritability estimates (broad-sense heritability ~80% cited in genetic literature background), not a single-gene Mendelian pattern. (riesmeijer2024agenomewideassociation pages 1-2, agren2023majorgeneticrisk pages 1-2)

10. Diagnostics

Clinical diagnosis and assessment

Diagnosis is largely clinical (nodules/cords with extension deficit). Severity is quantified via goniometry and Tubiana/TPED staging (see above). (khaliq2024dupuytrenscontracturea pages 4-5, khaliq2024dupuytrenscontracturea pages 6-7)

Imaging

• Ultrasound: used to identify nodules/cords and is increasingly studied as a biomarker tool (e.g., echogenicity, microvascularization) though not standard care. (khaliq2024dupuytrenscontracturea pages 4-5, NCT06956027 chunk 1)
• MRI: noted as possible adjunct for complex cases; a 2024 stage-0 nodule trial protocol reports ultrasound and MRI are being performed for quantification. (khaliq2024dupuytrenscontracturea pages 4-5, NCT06321991 chunk 1)

PROMs / functional measures

DASH, MHQ, PEM are reported; URAM and quickDASH appear prominently in trials and recent percutaneous series. (khaliq2024dupuytrenscontracturea pages 4-5, basile2024challengesandinnovations pages 2-4)

Differential diagnosis

Not extractable from the retrieved evidence in this run; would require clinical guideline or comprehensive review sources beyond the current context.

11. Outcome / prognosis

Recurrence and clinical course

High recurrence after intervention is repeatedly emphasized, and definitions vary widely; one cited recurrence definition requires >20° passive extension deficit in a treated joint plus a palpable cord compared to 6–12 week post-op baseline. (khaliq2024dupuytrenscontracturea pages 6-7, khaliq2024dupuytrenscontracturea pages 5-6)

Mortality

Robust disease-associated mortality statistics were not extractable from full-text evidence in this run. An administrative dataset reports 67 deaths (<1%) during DC admissions, which does not establish disease-specific mortality. (gerber2011dupuytrenscontracturea pages 2-4)

12. Treatment

Minimally invasive interventions (real-world use)

Collagenase clostridium histolyticum (CCH) injection (e.g., Xiaflex/Xiapex; enzymatic fasciotomy) (MAXO suggestion: enzymatic fasciotomy / intralesional enzyme injection): - Review-level ranges: success ~65–85%; recurrence ~35–40% within 5 years. (khaliq2024dupuytrenscontracturea pages 4-5) - Systematic review (quantitative): among 2675 patients, 94% had ≥1 AE; common AEs: edema 64%, extremity pain 53%, contusion 51%; recurrence in 23% of successfully treated joints (20% MCP, 28% PIP) with ≥12 months follow-up. (sandler2022treatmentofdupuytren’s pages 1-2) - 5-year cohort outcomes: no re-treatment estimate 79% (MCP) vs 49% (PIP); suggests durability is substantially worse for PIP joints. (werlinrud2018fiveyearresultsafter pages 1-2)

Percutaneous needle aponeurotomy/fasciotomy (PNA/PNF) (MAXO: percutaneous needle fasciotomy): - Advanced-disease (Tubiana 3–4) multicentre series (n=480): baseline PED 113° improved to PED 9° at 12 months; quickDASH improved from 24 to 8; URAM from 37 to 6; recurrence 30% at 12 months; minor complications 18.7% (mostly skin lacerations), no major complications. (basile2024challengesandinnovations pages 2-4, basile2024challengesandinnovations pages 1-2) - Separate retrospective PNA series (41 patients; mean follow-up 45 months) reported recurrence 58.5%, with lower recurrence when performed at early stage 1. (koroglu2024recurrenceandfactors pages 1-2)

Comparative complications and satisfaction (CCH vs limited fasciectomy) A 2024 systematic review/meta-analysis (967 patients; 1344 joints; mean follow-up ~19 months) reported more complications per patient with CCH (~2.15/patient) vs limited fasciectomy (~0.25/patient), with differing complication profiles (bruising/edema common for CCH; paraesthesia/scar sequelae/neuropraxia more common for surgery). (alhebshi2024comparingcomplicationsand pages 1-2)

Surgical interventions

Surgical options include limited fasciectomy, radical fasciectomy, and dermofasciectomy. Limited fasciectomy is described as preferred standard surgery but may have recurrence up to ~50% within 5–10 years; radical fasciectomy reduces recurrence but increases complication risk; dermofasciectomy lowers recurrence likelihood but is more complex (e.g., graft failure/infection risks). (khaliq2024dupuytrenscontracturea pages 5-6)

Early-stage and emerging therapies

Corticosteroid injections for nodules (MAXO: intralesional corticosteroid injection) - Used early to reduce inflammation and temporarily reduce nodule size/pain, but do not prevent contracture; effects are temporary and may require repeat injections. (khaliq2024dupuytrenscontracturea pages 5-6)

Radiotherapy (MAXO: radiotherapy) - Low-dose radiotherapy is used mainly in Europe for early disease; a cited 2016 study reported prevention of advancement in ~70% with minimal side effects, but long-term efficacy remains under study. (khaliq2024dupuytrenscontracturea pages 5-6)

Anti-TNF (adalimumab) intranodular injection (repurposing strategy) - RIDD trial-based economic evaluation: adalimumab reduced nodule hardness and size and nodules continued to decrease up to 18 months; within-trial ICER was £503,410/QALY at 12 months (not cost-effective short-term), but lifetime modelling suggested repeated courses could be cost-effective (£14,593/QALY; 77% probability at £20,000/QALY threshold). (dakin2022costeffectivenessofadalimumab pages 1-2, dakin2022costeffectivenessofadalimumab pages 5-6)

13. Prevention

No established primary prevention is demonstrated in the retrieved evidence. Practical prevention-like strategies include reducing modifiable risks (smoking, heavy alcohol, occupational exposures) and early surveillance in higher-risk populations; occupational-health sources suggest surveillance among vibration-exposed workers. (nilssonUnknownyeardupuytrenssjukdomi pages 35-38, samulenas2022theroleof pages 7-8)

Early-stage “secondary prevention” (delaying progression) remains an active research area, with radiotherapy, steroids, and biologic repurposing (adalimumab) studied primarily via surrogate outcomes (nodule size/hardness). (khaliq2024dupuytrenscontracturea pages 5-6, dakin2022costeffectivenessofadalimumab pages 6-8)

14. Other species / natural disease

Not addressed in the retrieved evidence for this run.

15. Model organisms

Not addressed in the retrieved evidence for this run.

Recent developments (2023–2024 emphasis) and expert analysis

Genetics and pathway discovery

The 2024 Nature Communications meta-GWAS represents a major advance in locus discovery, variance explained, and pathway/cell-type prioritization (Hedgehog/Notch; fibroblast/myofibroblast involvement), supporting target discovery directions. (riesmeijer2024agenomewideassociation pages 1-2, riesmeijer2024agenomewideassociation pages 2-4)

A retrieved figure set from this study (e.g., Manhattan plot, gene/cell prioritization, PRS separation) can be cited for visual support of genome-wide association strength and PRS discrimination. (riesmeijer2024agenomewideassociation media 9c685f33, riesmeijer2024agenomewideassociation media 069361fc)

Clinical research emphasis

2024 clinical work continues to focus on minimizing morbidity while improving durability (e.g., advanced-stage PNF outcomes and complications; collagenase vs fasciectomy comparative synthesis), while emphasizing the need for standardized recurrence definitions and outcome measures. (basile2024challengesandinnovations pages 2-4, khaliq2024dupuytrenscontracturea pages 6-7)

Key data gaps / limitations of this report

1) MONDO/Orphanet/OMIM identifiers, HPO/GO/CL/UBERON IDs, and PMIDs were not consistently present in the retrieved evidence chunks; terms are suggested but IDs should be added via dedicated ontology queries. (NCT06321991 chunk 2, khaliq2024dupuytrenscontracturea pages 4-5) 2) Disease-specific mortality/prognosis beyond recurrence was not extractable from available full-text evidence in this run. (gerber2011dupuytrenscontracturea pages 2-4) 3) Several high-priority 2023–2024 comparative effectiveness studies and guidelines were listed as “unobtainable” in tool output and could not be extracted for this report.

URLs and publication dates (selected high-value sources)

• Riesmeijer et al., Nature Communications (2024-01): https://doi.org/10.1038/s41467-023-44451-0 (riesmeijer2024agenomewideassociation pages 1-2)
• Ågren et al., Molecular Biology and Evolution (2023-06): https://doi.org/10.1093/molbev/msad130 (agren2023majorgeneticrisk pages 1-2)
• Khaliq & Orji, Cureus (2024-12): https://doi.org/10.7759/cureus.74945 (khaliq2024dupuytrenscontracturea pages 1-2)
• Alhebshi et al., Cureus (2024-01): https://doi.org/10.7759/cureus.53147 (alhebshi2024comparingcomplicationsand pages 1-2)
• Basile et al., J Orthop Surg Res (2024-07): https://doi.org/10.1186/s13018-024-04844-3 (basile2024challengesandinnovations pages 2-4)
• Sandler et al., HAND (2022-01): https://doi.org/10.1177/1558944720974119 (sandler2022treatmentofdupuytren’s pages 1-2)
• Dakin et al., Bone & Joint Open (2022-11): https://doi.org/10.1302/2633-1462.311.bjo-2022-0103.r2 (dakin2022costeffectivenessofadalimumab pages 1-2)

References

1. (khaliq2024dupuytrenscontracturea pages 1-2): Farihah Khaliq and Chijioke Orji. Dupuytren's contracture: a review of the literature. Cureus, Dec 2024. URL: https://doi.org/10.7759/cureus.74945, doi:10.7759/cureus.74945. This article has 13 citations.

2. (riesmeijer2024agenomewideassociation pages 1-2): Sophie A. Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B. Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M. N. Werker, Dominic Furniss, and Ilja M. Nolte. A genome-wide association meta-analysis implicates hedgehog and notch signaling in dupuytren’s disease. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44451-0, doi:10.1038/s41467-023-44451-0. This article has 21 citations and is from a highest quality peer-reviewed journal.

3. (riesmeijer2024agenomewideassociation pages 2-4): Sophie A. Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B. Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M. N. Werker, Dominic Furniss, and Ilja M. Nolte. A genome-wide association meta-analysis implicates hedgehog and notch signaling in dupuytren’s disease. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44451-0, doi:10.1038/s41467-023-44451-0. This article has 21 citations and is from a highest quality peer-reviewed journal.

4. (khaliq2024dupuytrenscontracturea pages 4-5): Farihah Khaliq and Chijioke Orji. Dupuytren's contracture: a review of the literature. Cureus, Dec 2024. URL: https://doi.org/10.7759/cureus.74945, doi:10.7759/cureus.74945. This article has 13 citations.

5. (khaliq2024dupuytrenscontracturea pages 5-6): Farihah Khaliq and Chijioke Orji. Dupuytren's contracture: a review of the literature. Cureus, Dec 2024. URL: https://doi.org/10.7759/cureus.74945, doi:10.7759/cureus.74945. This article has 13 citations.

6. (NCT06321991 chunk 2): Nodular Shrinking in Dupuytren Disease. Universitaire Ziekenhuizen KU Leuven. 2024. ClinicalTrials.gov Identifier: NCT06321991

7. (NCT07470684 chunk 2): Skin Involvement in Dupuytren Surgical Treatment Outcome. Universitaire Ziekenhuizen KU Leuven. 2024. ClinicalTrials.gov Identifier: NCT07470684

8. (NCT01876498 chunk 1): Daniel Herren. Registry of Patient With M. Dupuytren and Validation of the Brief MHQ. Schulthess Klinik. 2013. ClinicalTrials.gov Identifier: NCT01876498

9. (khaliq2024dupuytrenscontracturea pages 6-7): Farihah Khaliq and Chijioke Orji. Dupuytren's contracture: a review of the literature. Cureus, Dec 2024. URL: https://doi.org/10.7759/cureus.74945, doi:10.7759/cureus.74945. This article has 13 citations.

10. (NCT04874870 chunk 2): Jason Nydick DO. Effectiveness of Splinting After Collagenase Injection. Foundation for Orthopaedic Research and Education. 2021. ClinicalTrials.gov Identifier: NCT04874870

11. (NCT06956027 chunk 2): Ultrasound Features of Dupuytren's Disease. Universitaire Ziekenhuizen KU Leuven. 2025. ClinicalTrials.gov Identifier: NCT06956027

12. (NCT03192020 chunk 3): Olli Leppänen. Trial Comparing Treatment Strategies in Dupuytren's Contracture. Tampere University. 2017. ClinicalTrials.gov Identifier: NCT03192020

13. (alhebshi2024comparingcomplicationsand pages 1-2): Zainah A Alhebshi, Aya O Bamuqabel, Zainab Alqurain, Dana Dahlan, Hanan I Wasaya, Ziyad S Al Saedi, Gutaybah S Alqarni, Danah Alqarni, and Bayan Ghalimah. Comparing complications and patient satisfaction following injectable collagenase versus limited fasciectomy for dupuytren’s disease: a systematic review and meta-analysis. Cureus, Jan 2024. URL: https://doi.org/10.7759/cureus.53147, doi:10.7759/cureus.53147. This article has 9 citations.

14. (NCT06142929 chunk 2): Micronerves in Dupuytren and the Impact of Its Dissection on Recurrence. Universitaire Ziekenhuizen KU Leuven. 2024. ClinicalTrials.gov Identifier: NCT06142929

15. (gerber2011dupuytrenscontracturea pages 1-2): Robert A Gerber, Richard Perry, Robin Thompson, and Christopher Bainbridge. Dupuytren's contracture: a retrospective database analysis to assess clinical management and costs in england. BMC Musculoskeletal Disorders, 12:73-73, Apr 2011. URL: https://doi.org/10.1186/1471-2474-12-73, doi:10.1186/1471-2474-12-73. This article has 66 citations and is from a peer-reviewed journal.

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Rahimov, Anne Lehtonen, Tim Lu, Natalie Bowers, Rion Pendergrass, Linda McCarthy, Amy Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa Miller, Xinli Hu, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen-Seppänen, Johanna Huhtakangas, Nina Mars, Ali Abbasi, Jeffrey Waring, Fedik Rahimov, Apinya Lertratanakul, Nizar Smaoui, Anne Lehtonen, David Close, Marla Hochfeld, Natalie Bowers, Rion Pendergrass, Jorge Esparza Gordillo, Kirsi Auro, Dawn Waterworth, Fabiana Farias, Kirsi Kalpala, Nan Bing, Xinli Hu, Tarja Laitinen, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Riitta Lahesmaa, Nizar Smaoui, Alex Mackay, Glenda Lassi, Susan Eaton, Hubert Chen, Rion Pendergrass, Natalie Bowers, Joanna Betts, Kirsi Auro, Rajashree Mishra, Majd Mouded, Debby Ngo, Teemu Niiranen, Felix Vaura, Veikko Salomaa, Kaj Metsärinne, Jenni Aittokallio, Mika Kähönen, Jussi Hernesniemi, Daniel Gordin, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Jari Laukkanen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Benjamin Challis, Dirk Paul, Julie Hunkapiller, Natalie Bowers, Rion Pendergrass, Audrey Chu, Kirsi Auro, Dermot Reilly, Mike Mendelson, Jaakko Parkkinen, Melissa Miller, Tuomo Meretoja, Heikki Joensuu, Olli Carpén, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Päivi Auvinen, Klaus Elenius, Johanna Schleutker, Esa Pitkänen, Nina Mars, Mark Daly, Relja Popovic, Jeffrey Waring, Bridget Riley-Gillis, Anne Lehtonen, Jennifer Schutzman, Julie Hunkapiller, Natalie Bowers, Rion Pendergrass, Diptee Kulkarni, Kirsi Auro, Alessandro Porello, Andrey Loboda, Heli Lehtonen, Stefan McDonough, Sauli Vuoti, Kai Kaarniranta, Joni A Turunen, Terhi Ollila, Hannu Uusitalo, Juha Karjalainen, Esa Pitkänen, Mengzhen Liu, Heiko Runz, Stephanie Loomis, Erich Strauss, Natalie Bowers, Hao Chen, Rion Pendergrass, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen, David Choy, Rion Pendergrass, Dawn Waterworth, Kirsi Kalpala, Ying Wu, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipilä, Rion Pendergrass, Hannele Laivuori, Venla Kurra, Laura Kotaniemi-Talonen, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Varpu Jokimaa, Johannes Kettunen, Marja Vääräsmäki, Outi Uimari, Laure Morin-Papunen, Maarit Niinimäki, Terhi Piltonen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Mary Pat Reeve, Mark Daly, Niko Välimäki, Eija Laakkonen, Jaakko Tyrmi, Heidi Silven, Eeva Sliz, Riikka Arffman, Susanna Savukoski, Triin Laisk, Natalia Pujol, Mengzhen Liu, Bridget Riley-Gillis, Rion Pendergrass, Janet Kumar, Kirsi Auro, Iiris Hovatta, Chia-Yen Chen, Erkki Isometsä, Kumar Veerapen, Hanna Ollila, Jaana Suvisaari, Thomas Damm Als, Antti Mäkitie, Argyro Bizaki-Vallaskangas, Sanna Toppila-Salmi, Tytti Willberg, Elmo Saarentaus, Antti Aarnisalo, Eveliina Salminen, Elisa Rahikkala, Johannes Kettunen, Kristiina Aittomäki, Fredrik Åberg, Mitja Kurki, Samuli Ripatti, Mark Daly, Juha Karjalainen, Aki Havulinna, Juha Mehtonen, Priit Palta, Shabbeer Hassan, Pietro Della Briotta Parolo, Wei Zhou, Mutaamba Maasha, Kumar Veerapen, Shabbeer Hassan, Susanna Lemmelä, Manuel Rivas, Mari E Niemi, Aarno Palotie, Aoxing Liu, Arto Lehisto, Andrea Ganna, Vincent Llorens, Hannele Laivuori, Taru Tukiainen, Mary Pat Reeve, Henrike Heyne, Nina Mars, Joel Rämö, Elmo Saarentaus, Hanna Ollila, Rodos Rodosthenous, Satu Strausz, Tuula Palotie, Kimmo Palin, Javier Garcia-Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Amanda Elliott, Kati Kristiansson, Mikko Arvas, Kati Hyvärinen, Jarmo Ritari, Olli Carpén, Johannes Kettunen, Katri Pylkäs, Eeva Sliz, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Arto Mannermaa, Eija Laakkonen, Nina Pitkänen, Samuel Lessard, Clément Chatelain, Perttu Terho, Sirpa Soini, Jukka Partanen, Eero Punkka, Raisa Serpi, Sanna Siltanen, Veli-Matti Kosma, Teijo Kuopio, Anu Jalanko, Huei-Yi Shen, Risto Kajanne, Mervi Aavikko, Mitja Kurki, Juha Karjalainen, Pietro Della Briotta Parolo, Arto Lehisto, Juha Mehtonen, Wei Zhou, Masahiro Kanai, Mutaamba Maasha, Kumar Veerapen, Hannele Laivuori, Aki Havulinna, Susanna Lemmelä, Tuomo Kiiskinen, L Elisa Lahtela, Mari Kaunisto, Elina Kilpeläinen, Timo P Sipilä, Oluwaseun Alexander Dada, Awaisa Ghazal, Anastasia Kytölä, Rigbe Weldatsadik, Kati Donner, Timo P Sipilä, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Auli Toivola, Minna Brunfeldt, Hannele Mattsson, Kati Kristiansson, Susanna Lemmelä, Sami Koskelainen, Tero Hiekkalinna, Teemu Paajanen, Priit Palta, Kalle Pärn, Mart Kals, Shuang Luo, Vishal Sinha, Tarja Laitinen, Mary Pat Reeve, Marianna Niemi, Kumar Veerapen, Harri Siirtola, Javier Gracia-Tabuenca, Mika Helminen, Tiina Luukkaala, Iida Vähätalo, Jyrki Pitkänen, Marco Hautalahti, Johanna Mäkelä, Sarah Smith, Tom Southerington, Kristoffer Sahlholm, Svante Pääbo, and Hugo Zeberg. Major genetic risk factors for dupuytren's disease are inherited from neandertals. Molecular Biology and Evolution, Jun 2023. URL: https://doi.org/10.1093/molbev/msad130, doi:10.1093/molbev/msad130. This article has 18 citations and is from a highest quality peer-reviewed journal.

17. (agren2023majorgeneticrisk pages 2-3): Richard Ågren, Snehal Patil, Xiang Zhou, Aarno Palotie, Mark Daly, Bridget Riley-Gills, Howard Jacob, Dirk Paul, Athena Matakidou, Adam Platt, Heiko Runz, Sally John, George Okafo, Nathan Lawless, Robert Plenge, Joseph Maranville, Mark McCarthy, Julie Hunkapiller, Margaret G Ehm, Kirsi Auro, Simonne Longerich, Caroline Fox, Anders Mälarstig, Katherine Klinger, Deepak Raipal, Eric Green, Robert Graham, Robert Yang, Chris ÓDonnell, Tomi Mäkelä, Jaakko Kaprio, Petri Virolainen, Antti Hakanen, Terhi Kilpi, Markus Perola, Jukka Partanen, Anne Pitkäranta, Juhani Junttila, Raisa Serpi, Tarja Laitinen, Veli-Matti Kosma, Jari Laukkanen, Marco Hautalahti, Outi Tuovila, Raimo Pakkanen, Jeffrey Waring, Bridget Riley-Gillis, Fedik Rahimov, Ioanna Tachmazidou, Chia-Yen Chen, Heiko Runz, Zhihao Ding, Marc Jung, Shameek Biswas, Rion Pendergrass, Julie Hunkapiller, Margaret G Ehm, David Pulford, Neha Raghavan, Adriana Huertas-Vazquez, Jae-Hoon Sul, Anders Mälarstig, Xinli Hu, Katherine Klinger, Robert Graham, Eric Green, Sahar Mozaffari, Dawn Waterworth, Nicole Renaud, Máen Obeidat, Samuli Ripatti, Johanna Schleutker, Markus Perola, Mikko Arvas, Olli Carpén, Reetta Hinttala, Johannes Kettunen, Arto Mannermaa, Katriina Aalto-Setälä, Mika Kähönen, Jari Laukkanen, Johanna Mäkelä, Reetta Kälviäinen, Valtteri Julkunen, Hilkka Soininen, Anne Remes, Mikko Hiltunen, Jukka Peltola, Minna Raivio, Pentti Tienari, Juha Rinne, Roosa Kallionpää, Juulia Partanen, Ali Abbasi, Adam Ziemann, Nizar Smaoui, Anne Lehtonen, Susan Eaton, Heiko Runz, Sanni Lahdenperä, Shameek Biswas, Julie Hunkapiller, Natalie Bowers, Edmond Teng, Rion Pendergrass, Fanli Xu, David Pulford, Kirsi Auro, Laura Addis, John Eicher, Qingqin S Li, Karen He, Ekaterina Khramtsova, Neha Raghavan, Martti Färkkilä, Jukka Koskela, Sampsa Pikkarainen, Airi Jussila, Katri Kaukinen, Timo Blomster, Mikko Kiviniemi, Markku Voutilainen, Mark Daly, Ali Abbasi, Jeffrey Waring, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen, Tim Lu, Natalie Bowers, Rion Pendergrass, Linda McCarthy, Amy Hart, Meijian Guan, Jason Miller, Kirsi Kalpala, Melissa Miller, Xinli Hu, Kari Eklund, Antti Palomäki, Pia Isomäki, Laura Pirilä, Oili Kaipiainen-Seppänen, Johanna Huhtakangas, Nina Mars, Ali Abbasi, Jeffrey Waring, Fedik Rahimov, Apinya Lertratanakul, Nizar Smaoui, Anne Lehtonen, David Close, Marla Hochfeld, Natalie Bowers, Rion Pendergrass, Jorge Esparza Gordillo, Kirsi Auro, Dawn Waterworth, Fabiana Farias, Kirsi Kalpala, Nan Bing, Xinli Hu, Tarja Laitinen, Margit Pelkonen, Paula Kauppi, Hannu Kankaanranta, Terttu Harju, Riitta Lahesmaa, Nizar Smaoui, Alex Mackay, Glenda Lassi, Susan Eaton, Hubert Chen, Rion Pendergrass, Natalie Bowers, Joanna Betts, Kirsi Auro, Rajashree Mishra, Majd Mouded, Debby Ngo, Teemu Niiranen, Felix Vaura, Veikko Salomaa, Kaj Metsärinne, Jenni Aittokallio, Mika Kähönen, Jussi Hernesniemi, Daniel Gordin, Juha Sinisalo, Marja-Riitta Taskinen, Tiinamaija Tuomi, Timo Hiltunen, Jari Laukkanen, Amanda Elliott, Mary Pat Reeve, Sanni Ruotsalainen, Benjamin Challis, Dirk Paul, Julie Hunkapiller, Natalie Bowers, Rion Pendergrass, Audrey Chu, Kirsi Auro, Dermot Reilly, Mike Mendelson, Jaakko Parkkinen, Melissa Miller, Tuomo Meretoja, Heikki Joensuu, Olli Carpén, Johanna Mattson, Eveliina Salminen, Annika Auranen, Peeter Karihtala, Päivi Auvinen, Klaus Elenius, Johanna Schleutker, Esa Pitkänen, Nina Mars, Mark Daly, Relja Popovic, Jeffrey Waring, Bridget Riley-Gillis, Anne Lehtonen, Jennifer Schutzman, Julie Hunkapiller, Natalie Bowers, Rion Pendergrass, Diptee Kulkarni, Kirsi Auro, Alessandro Porello, Andrey Loboda, Heli Lehtonen, Stefan McDonough, Sauli Vuoti, Kai Kaarniranta, Joni A Turunen, Terhi Ollila, Hannu Uusitalo, Juha Karjalainen, Esa Pitkänen, Mengzhen Liu, Heiko Runz, Stephanie Loomis, Erich Strauss, Natalie Bowers, Hao Chen, Rion Pendergrass, Kaisa Tasanen, Laura Huilaja, Katariina Hannula-Jouppi, Teea Salmi, Sirkku Peltonen, Leena Koulu, Nizar Smaoui, Fedik Rahimov, Anne Lehtonen, David Choy, Rion Pendergrass, Dawn Waterworth, Kirsi Kalpala, Ying Wu, Pirkko Pussinen, Aino Salminen, Tuula Salo, David Rice, Pekka Nieminen, Ulla Palotie, Maria Siponen, Liisa Suominen, Päivi Mäntylä, Ulvi Gursoy, Vuokko Anttonen, Kirsi Sipilä, Rion Pendergrass, Hannele Laivuori, Venla Kurra, Laura Kotaniemi-Talonen, Oskari Heikinheimo, Ilkka Kalliala, Lauri Aaltonen, Varpu Jokimaa, Johannes Kettunen, Marja Vääräsmäki, Outi Uimari, Laure Morin-Papunen, Maarit Niinimäki, Terhi Piltonen, Katja Kivinen, Elisabeth Widen, Taru Tukiainen, Mary Pat Reeve, Mark Daly, Niko Välimäki, Eija Laakkonen, Jaakko Tyrmi, Heidi Silven, Eeva Sliz, Riikka Arffman, Susanna Savukoski, Triin Laisk, Natalia Pujol, Mengzhen Liu, Bridget Riley-Gillis, Rion Pendergrass, Janet Kumar, Kirsi Auro, Iiris Hovatta, Chia-Yen Chen, Erkki Isometsä, Kumar Veerapen, Hanna Ollila, Jaana Suvisaari, Thomas Damm Als, Antti Mäkitie, Argyro Bizaki-Vallaskangas, Sanna Toppila-Salmi, Tytti Willberg, Elmo Saarentaus, Antti Aarnisalo, Eveliina Salminen, Elisa Rahikkala, Johannes Kettunen, Kristiina Aittomäki, Fredrik Åberg, Mitja Kurki, Samuli Ripatti, Mark Daly, Juha Karjalainen, Aki Havulinna, Juha Mehtonen, Priit Palta, Shabbeer Hassan, Pietro Della Briotta Parolo, Wei Zhou, Mutaamba Maasha, Kumar Veerapen, Shabbeer Hassan, Susanna Lemmelä, Manuel Rivas, Mari E Niemi, Aarno Palotie, Aoxing Liu, Arto Lehisto, Andrea Ganna, Vincent Llorens, Hannele Laivuori, Taru Tukiainen, Mary Pat Reeve, Henrike Heyne, Nina Mars, Joel Rämö, Elmo Saarentaus, Hanna Ollila, Rodos Rodosthenous, Satu Strausz, Tuula Palotie, Kimmo Palin, Javier Garcia-Tabuenca, Harri Siirtola, Tuomo Kiiskinen, Jiwoo Lee, Kristin Tsuo, Amanda Elliott, Kati Kristiansson, Mikko Arvas, Kati Hyvärinen, Jarmo Ritari, Olli Carpén, Johannes Kettunen, Katri Pylkäs, Eeva Sliz, Minna Karjalainen, Tuomo Mantere, Eeva Kangasniemi, Sami Heikkinen, Arto Mannermaa, Eija Laakkonen, Nina Pitkänen, Samuel Lessard, Clément Chatelain, Perttu Terho, Sirpa Soini, Jukka Partanen, Eero Punkka, Raisa Serpi, Sanna Siltanen, Veli-Matti Kosma, Teijo Kuopio, Anu Jalanko, Huei-Yi Shen, Risto Kajanne, Mervi Aavikko, Mitja Kurki, Juha Karjalainen, Pietro Della Briotta Parolo, Arto Lehisto, Juha Mehtonen, Wei Zhou, Masahiro Kanai, Mutaamba Maasha, Kumar Veerapen, Hannele Laivuori, Aki Havulinna, Susanna Lemmelä, Tuomo Kiiskinen, L Elisa Lahtela, Mari Kaunisto, Elina Kilpeläinen, Timo P Sipilä, Oluwaseun Alexander Dada, Awaisa Ghazal, Anastasia Kytölä, Rigbe Weldatsadik, Kati Donner, Timo P Sipilä, Anu Loukola, Päivi Laiho, Tuuli Sistonen, Essi Kaiharju, Markku Laukkanen, Elina Järvensivu, Sini Lähteenmäki, Lotta Männikkö, Regis Wong, Auli Toivola, Minna Brunfeldt, Hannele Mattsson, Kati Kristiansson, Susanna Lemmelä, Sami Koskelainen, Tero Hiekkalinna, Teemu Paajanen, Priit Palta, Kalle Pärn, Mart Kals, Shuang Luo, Vishal Sinha, Tarja Laitinen, Mary Pat Reeve, Marianna Niemi, Kumar Veerapen, Harri Siirtola, Javier Gracia-Tabuenca, Mika Helminen, Tiina Luukkaala, Iida Vähätalo, Jyrki Pitkänen, Marco Hautalahti, Johanna Mäkelä, Sarah Smith, Tom Southerington, Kristoffer Sahlholm, Svante Pääbo, and Hugo Zeberg. Major genetic risk factors for dupuytren's disease are inherited from neandertals. Molecular Biology and Evolution, Jun 2023. URL: https://doi.org/10.1093/molbev/msad130, doi:10.1093/molbev/msad130. This article has 18 citations and is from a highest quality peer-reviewed journal.

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34. (koroglu2024recurrenceandfactors pages 1-2): Muhammed Köroğlu, Kadir Ertem, Ekrem Özdemir, Gültekin Taşkıran, Mustafa Karakaplan, Emre Ergen, İpek Balıkçı Çiçek, Hüseyin Utku Özdeş, and Okan Aslantürk. Recurrence and factors associated with recurrence in dupuytren's disease patients treated with percutaneous needle aponeurotomy. European Journal of Therapeutics, 30:823-832, Dec 2024. URL: https://doi.org/10.58600/eurjther2500, doi:10.58600/eurjther2500. This article has 0 citations.

35. (dakin2022costeffectivenessofadalimumab pages 1-2): Helen Dakin, Ines Rombach, Melina Dritsaki, Alastair Gray, Catherine Ball, Sarah E. Lamb, and Jagdeep Nanchahal. Cost-effectiveness of adalimumab for early-stage dupuytren’s disease. Bone & Joint Open, 3:898-906, Nov 2022. URL: https://doi.org/10.1302/2633-1462.311.bjo-2022-0103.r2, doi:10.1302/2633-1462.311.bjo-2022-0103.r2. This article has 7 citations and is from a peer-reviewed journal.

36. (dakin2022costeffectivenessofadalimumab pages 5-6): Helen Dakin, Ines Rombach, Melina Dritsaki, Alastair Gray, Catherine Ball, Sarah E. Lamb, and Jagdeep Nanchahal. Cost-effectiveness of adalimumab for early-stage dupuytren’s disease. Bone & Joint Open, 3:898-906, Nov 2022. URL: https://doi.org/10.1302/2633-1462.311.bjo-2022-0103.r2, doi:10.1302/2633-1462.311.bjo-2022-0103.r2. This article has 7 citations and is from a peer-reviewed journal.

37. (dakin2022costeffectivenessofadalimumab pages 6-8): Helen Dakin, Ines Rombach, Melina Dritsaki, Alastair Gray, Catherine Ball, Sarah E. Lamb, and Jagdeep Nanchahal. Cost-effectiveness of adalimumab for early-stage dupuytren’s disease. Bone & Joint Open, 3:898-906, Nov 2022. URL: https://doi.org/10.1302/2633-1462.311.bjo-2022-0103.r2, doi:10.1302/2633-1462.311.bjo-2022-0103.r2. This article has 7 citations and is from a peer-reviewed journal.

38. (riesmeijer2024agenomewideassociation media 069361fc): Sophie A. Riesmeijer, Zoha Kamali, Michael Ng, Dmitriy Drichel, Bram Piersma, Kerstin Becker, Thomas B. Layton, Jagdeep Nanchahal, Michael Nothnagel, Ahmad Vaez, Hans Christian Hennies, Paul M. N. Werker, Dominic Furniss, and Ilja M. Nolte. A genome-wide association meta-analysis implicates hedgehog and notch signaling in dupuytren’s disease. Nature Communications, Jan 2024. URL: https://doi.org/10.1038/s41467-023-44451-0, doi:10.1038/s41467-023-44451-0. This article has 21 citations and is from a highest quality peer-reviewed journal.

Artifacts

• Edison artifact artifact-00
• Edison artifact artifact-01