Aliases: I-Rel, c-Rel, HIVEN86A.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Classic Hodgkin Lymphoma | somatic driver somatic |
mechanism: Mutation-Driven NF-kappaB Activation
|
| Immunodeficiency 92 | causative germline |
mechanism: Absent c-Rel Protein; Biallelic Loss-of-Function REL Variants
|
| Atopic Dermatitis |
untyped
GWAS
|
|
| Multiple Sclerosis |
untyped
GWAS
|
|
| Psoriasis |
untyped
GWAS
|
|
| Rheumatoid Arthritis |
untyped
GWAS
|
mechanism: NF-κB Activation
|
| Systemic Lupus Erythematosus |
untyped
GWAS
|
|
| Ulcerative Colitis |
untyped
GWAS
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| immunodeficiency 92 MONDO:0030498 | AR | Moderate 2025-12-18 |
Immunodeficiency 92
causative
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.