Browse All / Genes / MAPK1

MAPK1

mitogen-activated protein kinase 1
2 disorders 1 no genetic record 1 causative 22q11.22 gene with protein product
HGNC:6871MonarchNCBI Gene 5594ENSG00000100030UniProt P28482OMIM 176948

Previous symbols: PRKM2, PRKM1. Aliases: ERK, ERK2, p41mapk, MAPK2.

Normal function · from ai-gene-review (P28482, commit e7236877cf14) · AI-generated, not KB evidence

MAPK1 (ERK2) is an ATP-dependent, proline-directed serine/threonine MAP kinase in the canonical Ras-RAF-MEK-ERK cascade. It is activated by MEK1/2 dual phosphorylation, phosphorylates cytosolic and nuclear substrates, and shuttles between cytoplasmic/cytosolic and nuclear compartments after stimulation. Distal proliferation, differentiation, apoptosis, migration, transcriptional, and disease phenotypes are context-dependent ERK pathway outputs rather than the core MAPK1 molecular function.

MAPK1/ERK2 is an ATP-dependent, proline-directed serine/threonine MAP kinase. After MEK1/2-mediated activation, ERK2 phosphorylates protein substrates and transmits canonical Ras-RAF-MEK-ERK signals to cytosolic and nuclear targets.
molecular function: MAP kinase activity · directly involved in: ERK1 and ERK2 cascade; MAPK cascade; protein phosphorylation · locations: cytosol; cytoplasm; nucleus
ATP binding is a core active-site function of MAPK1 because ATP/MgATP provides the phosphoryl group used for ERK2 serine/threonine protein kinase catalysis.
molecular function: ATP binding · directly involved in: protein phosphorylation · locations: cytosol; nucleus
In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Noonan Syndrome causative
mechanism: ERK Cascade Hyperactivation
subtype: NS13
scoped to subtype: NS13
MOS-related Oocyte Zygote Embryo Maturation Arrest no genetic record
mechanism: Oocyte MEK-ERK1/2 Cascade Inactivation

Identity from HGNC (snapshot 2026-10-24). Page layers are described in the gene pages documentation.