MAP2K2

mitogen-activated protein kinase kinase 2

2 disorders 1 causative 1 untyped 19p13.3 gene with protein product

HGNC:6842 Monarch NCBI Gene 5605 ENSG00000126934 UniProt P36507 OMIM 601263

Previous symbols: PRKMK2. Aliases: MEK2, MKK2.

Normal function · from ai-gene-review (P36507, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status IN_PROGRESS; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Cardiofaciocutaneous Syndrome	causative	mechanism: MEK1 and MEK2 Kinase Hyperactivation subtype: CFC4 scoped to subtype: CFC4
Noonan Syndrome	untyped Pathogenic Variants

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
cardiofaciocutaneous syndrome MONDO:0015280	AD	Definitive 2018-07-24	Cardiofaciocutaneous Syndrome causative
Noonan syndrome MONDO:0018997	AD	Limited 2018-06-01	Noonan Syndrome untyped

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.