Previous symbols: MUM1. Aliases: LSIRF.
ai-gene-review has this gene at status DRAFT; the description is shown only once the review is complete. Read the draft upstream.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Celiac Disease | susceptibility | |
| Immunodeficiency 131 | causative |
animal model: Heterozygous Irf4 T95R knock-in mouse
|
| Rosacea | susceptibility | |
| Type I Diabetes | susceptibility germline | |
| Asthma |
untyped
GWAS
|
|
| Atopic Dermatitis |
untyped
GWAS
|
|
| Crohn Disease |
untyped
GWAS
|
|
| Psoriasis |
untyped
GWAS
|
|
| Rheumatoid Arthritis |
untyped
GWAS
|
|
| Systemic Lupus Erythematosus |
untyped
GWAS
|
|
| Vitiligo |
untyped
Associated
|
|
| Primary_Tonsillar_Lymphoma | no genetic record somatic |
mechanism: IRF4-rearranged Large B-cell Lymphoma
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| combined immunodeficiency MONDO:0015131 | AD | Definitive 2024-12-10 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.