Aliases: CD126, IL-6R, IL-1Ra, IL6RA, gp80.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Rheumatoid Arthritis |
untyped
Mediates IL-6 signaling
|
mechanism: JAK/STAT Signaling
|
| Major Depressive Disorder | no genetic record |
animal model: Microglial P2rx7 and Il6 and astrocytic Il6ra knockdown mice under chronic social defeat stress
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| hyper-IgE recurrent infection syndrome 5, autosomal recessive MONDO:0030069 | AR | Limited 2023-09-21 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.