Previous symbols: IFNB2. Aliases: IL-6, BSF2, HGF, HSF.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Legg-Calve-Perthes Disease | risk factor |
mechanism: Necrotic-Bone DAMP Release and Chronic Hip Synovitis
|
| Chronic_Obstructive_Pulmonary_Disease |
untyped
Interleukin-6 contributes to systemic inflammation.
|
|
| Monkeypox |
untyped
Upregulated during infection
|
|
| Multisystem Inflammatory Syndrome in Children (MIS-C) |
untyped
Implicated in cytokine storm pathophysiology
|
mechanism: Cytokine Storm
|
| Aflatoxin-Related Hepatocellular Carcinoma | no genetic record |
mechanism: AFB1-Induced NF-kappa B and IL-6 Signaling
|
| AIP-related pituitary adenoma predisposition | no genetic record |
mechanism: IL-6/STAT3 activation in AIP-mutant somatotrophs
|
| Androgenetic Alopecia | no genetic record |
mechanism: Increased IL6 Secretion
|
| Major Depressive Disorder | no genetic record |
animal model: Microglial P2rx7 and Il6 and astrocytic Il6ra knockdown mice under chronic social defeat stress
|
| Neuromyelitis Optica Spectrum Disorder with Anti-AQP4 Antibodies | no genetic record |
mechanism: Complement-Dependent Th17 Cytokine Amplification
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.