Previous symbols: C11orf43. Aliases: FLJ44734, IGF-II.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Embryonal Rhabdomyosarcoma | somatic driver somatic unknown |
mechanism: IGF2 Overexpression; Loss of Heterozygosity at 11p15
|
| Beckwith-Wiedemann Syndrome |
untyped
Imprinted growth promoter overexpressed in IC1 GoM and pUPD11
|
mechanism: 11p15.5 Imprinting Dysregulation; IGF2 Overexpression
scoped to subtype: IC1 GoM
|
| Silver-Russell Syndrome |
untyped
Rare causative gene and 11p15 imprinting target
|
mechanism: 11p15 Imprinting Dysregulation; Reduced Paternal IGF2 Expression
|
| Wilms Tumor |
untyped
Epigenetic Alteration
|
mechanism: IGF2 Loss of Imprinting
|
| 3-M Syndrome | no genetic record |
mechanism: Reduced IGF2 Expression
|
| WT1-Related Wilms Tumor Predisposition | no genetic record |
mechanism: Biallelic IGF2 Expression
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| Silver-Russell syndrome 3 MONDO:0014663 | AD | Definitive 2023-10-04 |
no dismech entry |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.