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GNA11

G protein subunit alpha 11
5 disorders 2 causative 1 no genetic record 1 untyped 1 somatic driver 19p13.3 gene with protein product
HGNC:4379MonarchNCBI Gene 2767ENSG00000088256UniProt P29992OMIM 139313

Previous symbols: HHC2. Aliases: FBH, FBH2, FHH2.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Familial Hypocalciuric Hypercalcemia 2 causative germline loss of function
mechanism: Heterozygous GNA11 Loss-of-Function Variant
Ocular Melanoma somatic driver somatic
mechanism: Gq/G11 Alpha Subunit Activating Mutation
subtype: Uveal Melanoma
scoped to subtype: Uveal Melanoma
Sturge-Weber Syndrome causative somatic
Nevus of Ota untyped
Causative
somatic
mechanism: Mosaic GNAQ-GNA11 Melanocyte Signaling
Meningeal Melanocytoma no genetic record
mechanism: G-alpha-q Pathway Activation
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.