FLG - dismech genes

Normal function · from ai-gene-review (P20930, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status unknown; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Ichthyosis Vulgaris	causative germline loss of function	mechanism: FLG Loss-of-Function Variants subtype: Mild IV; Severe IV
X-linked Reticulate Pigmentary Disorder	modifier
Atopic Dermatitis	untyped Associated	mechanism: Epidermal Barrier Dysfunction
Contact Dermatitis	untyped Risk Factor	scoped to subtype: Allergic Contact Dermatitis, Irritant Contact Dermatitis
Inherited Ichthyosis	untyped Causative biallelic loss-of-function variants in ichthyosis vulgaris	mechanism: Disrupted Keratinocyte Differentiation and Cornification subtype: Ichthyosis Vulgaris scoped to subtype: Ichthyosis Vulgaris

Mechanism modules · computed from kb/

epidermal_cornification_failure via Ichthyosis Vulgaris, Inherited Ichthyosis
epithelial_barrier_dysfunction via Atopic Dermatitis

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.