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DPYD

dihydropyrimidine dehydrogenase
4 disorders 3 risk factor 1 causative 1p21.3 gene with protein product
HGNC:3012MonarchNCBI Gene 1806ENSG00000188641UniProt Q12882OMIM 612779

Aliases: DPD, DHPDHase.

Normal function · from ai-gene-review (Q12882, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
5-Fluorouracil Poisoning risk factor
Chemotherapy-Induced Diarrhea risk factor germline
mechanism: Host pharmacogenetic variation in cytotoxic drug inactivation
Chemotherapy-Induced Neutropenia risk factor germline
mechanism: Host pharmacogenetic variation in cytotoxic drug inactivation
Dihydropyrimidine Dehydrogenase Deficiency causative

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.