Aliases: DYNII, DYN2, CMTDIB, CMTDI1, DI-CMTB, CMT2M.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Centronuclear Myopathy | causative |
mechanism: DNM2 dynamin-2 dysfunction
subtype: DNM2-CNM
scoped to subtype: DNM2-CNM
|
| Charcot-Marie-Tooth Disease Dominant Intermediate B | causative germline partial loss of function |
mechanism: DNM2 Variant Impairing Dynamin-2 Lipid Binding
|
| Intermediate Charcot-Marie-Tooth Disease | causative germline |
mechanism: DNM2 Membrane Remodeling Defect
subtype: DI-CMTB
scoped to subtype: DI-CMTB
|
| Lethal Congenital Contracture Syndrome | causative germline |
mechanism: Endocytic Trafficking Failure
subtype: LCCS5
scoped to subtype: LCCS5
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| autosomal dominant centronuclear myopathy MONDO:0008048 | AD | Definitive 2019-12-20 |
no dismech entry |
| Charcot-Marie-Tooth disease MONDO:0015626 | AD | Definitive 2020-10-27 |
Charcot-Marie-Tooth Disease
not named
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.