NEXN

nexilin F-actin binding protein

4 disorders 2 untyped 2 causative 1 disputed 1p31.1 gene with protein product

HGNC:29557 Monarch NCBI Gene 91624 ENSG00000162614 UniProt Q0ZGT2 OMIM 613121

Aliases: nexilin, NELIN.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Dilated Cardiomyopathy 1CC	causative	mechanism: Nexilin Loss of Function
Hypertrophic Cardiomyopathy 20	causativedisputed germline	mechanism: NEXN Missense Variants Impair Nexilin F-Actin Binding
Dilated Cardiomyopathy	untyped Pathogenic Variants	mechanism: Sarcomeric and Cytoskeletal Dysfunction
Hypertrophic Cardiomyopathy	untyped Pathogenic Variants	mechanism: Sarcomere Protein Mutations

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
hypertrophic cardiomyopathy MONDO:0005045	AD	Limited 2023-03-23	Hypertrophic Cardiomyopathy untyped
dilated cardiomyopathy 1CC MONDO:0013147	AD	Strong 2026-03-04	Dilated Cardiomyopathy 1CC causative

Mechanism modules · computed from kb/

cardiomyopathy_maladaptive_remodeling via Dilated Cardiomyopathy 1CC

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.