KRT74

keratin 74

2 disorders 1 untyped 1 causative 12q13.13 gene with protein product

HGNC:28929 Monarch NCBI Gene 121391 ENSG00000170484 UniProt Q7RTS7 OMIM 608248

Aliases: K6IRS4, KRT5C, KRT6IRS4.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
KRT74-Related Pure Hair-Nail Ectodermal Dysplasia	causative
Isolated Woolly Hair	untyped	mechanism: Inner Root Sheath Keratin Filament Defect subtype: ADWH scoped to subtype: ADWH

Mechanism modules · computed from kb/

keratin_intermediate_filament_fragility via Isolated Woolly Hair

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.