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HROB

homologous recombination factor with OB-fold
2 disorders 2 untyped 17q21.31 gene with protein product
HGNC:28460MonarchNCBI Gene 78995ENSG00000125319UniProt Q8N3J3OMIM 618611

Previous symbols: C17orf53. Aliases: MGC3130, MCM8IP.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
46,XX Gonadal Dysgenesis untyped
Biallelic HROB variants are candidate-to-moderate evidence for autosomal recessive ovarian insufficiency.
germline
mechanism: Meiotic Homologous-Recombination Failure
subtype: ODG11
scoped to subtype: ODG11
HROB-related gametogenic failure untyped
Causative (Primary)
mechanism: Impaired homologous recombination
Mechanism modules · computed from kb/

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.