MCM9

minichromosome maintenance 9 homologous recombination repair factor

2 disorders 1 causative 1 untyped 6q22.31 gene with protein product

HGNC:21484 Monarch NCBI Gene 254394 ENSG00000111877 UniProt Q9NXL9 OMIM 610098

Previous symbols: MCMDC1, C6orf61. Aliases: MGC35304, dJ329L24.3, FLJ20170.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
46,XX Gonadal Dysgenesis	causative germline	mechanism: Meiotic Homologous-Recombination Failure subtype: ODG4 scoped to subtype: ODG4
MCM9-related gametogenic failure	untyped Causative (Primary)	mechanism: Impaired homologous recombination; Impaired mismatch repair

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
MCM9-related gametogenic failure MONDO:1060226	AR	Definitive 2026-04-01	MCM9-related gametogenic failure untyped

Mechanism modules · computed from kb/

meiotic_prophase_failure via MCM9-related gametogenic failure

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.