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RRM2B

ribonucleotide reductase regulatory TP53 inducible subunit M2B
2 disorders 2 causative 8q22.3 gene with protein product
HGNC:17296MonarchNCBI Gene 50484ENSG00000048392UniProt Q7LG56OMIM 604712

Aliases: p53R2.

Normal function · from ai-gene-review (Q7LG56, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status INITIALIZED; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

DisorderRelationshipWhere the gene appears
Autosomal Dominant Progressive External Ophthalmoplegia causative germline
mechanism: Heterozygous Nuclear mtDNA-Maintenance Gene Variant
subtype: PEOA5
scoped to subtype: PEOA5
Mitochondrial Neurogastrointestinal Encephalomyopathy causative
scoped to subtype: MNGIE-like RRM2B

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.