Aliases: YAP65, YAP-1.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Uveal Coloboma-Cleft Lip and Palate-Intellectual Disability Syndrome | causative germline |
mechanism: Alternative Transcription Start Site Modulation of Phenotype Severity; Pleiotropic YAP1 Requirement Across Eye, Ear, Palate, and Kidney Primordia; Reduced YAP-TEAD Transcriptional Output in the Hippo Pathway; YAP1 Haploinsufficiency
variant: NM_001130145:c.1066G>T (p.Glu356*)
|
| Epithelioid Hemangioendothelioma |
untyped
Somatic gene fusion (YAP1-TFE3) in a minority subset
|
mechanism: YAP1-TFE3 Fusion Oncogene Formation
scoped to subtype: YAP1-TFE3
|
| Polycystic Ovary Syndrome |
untyped
Risk Factor
|
|
| Ewing Sarcoma | no genetic record |
mechanism: IGF-1/YAP1 Developmental Cooperation
discussion: (unnamed)
|
| Hepatocellular Carcinoma | no genetic record |
mechanism: YAP Nuclear Translocation
|
| Meningioma | no genetic record |
mechanism: Hippo-YAP Signaling Deregulation
|
| Pancreatic Ductal Adenocarcinoma | no genetic record |
mechanism: MYC Amplification-Driven RAS-Independent Proliferation
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.