VEGFA

vascular endothelial growth factor A

3 disorders 2 no genetic record 1 biomarker 6p21.1 gene with protein product

HGNC:12680 Monarch NCBI Gene 7422 ENSG00000112715 UniProt P15692 OMIM 192240

Previous symbols: VEGF. Aliases: VEGF-A, VPF.

Normal function · from ai-gene-review (P15692, commit 79fe13b38970) · AI-generated, not KB evidence

ai-gene-review has this gene at status IN_PROGRESS; the description is shown only once the review is complete. Read the draft upstream.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Preeclampsia	biomarker
Bacterial meningitis	no genetic record	mechanism: Blood-Brain Barrier Disruption
Gastric Adenocarcinoma	no genetic record	mechanism: Angiogenic Switch and VEGF-Driven Neovascularization

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
congenital heart disease MONDO:0005453	AD	Limited 2024-05-07	Congenital Heart Disease not named

Mechanism modules · computed from kb/

tumor_angiogenesis via Gastric Adenocarcinoma

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.