Previous symbols: UGT1, GNT1. Aliases: UGT1A.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Chemotherapy-Induced Diarrhea | risk factor germline |
mechanism: Host pharmacogenetic variation in cytotoxic drug inactivation
|
| Chemotherapy-Induced Neutropenia | risk factor germline |
mechanism: Host pharmacogenetic variation in cytotoxic drug inactivation
|
| Crigler-Najjar Syndrome | causative |
mechanism: Complete or Severe Loss of UGT1A1 Glucuronidation Activity
subtype: Type 1; Type 2
|
| Gilbert's Syndrome | causativeprotective |
mechanism: Impaired Glucuronidation of Drugs and Drug Metabolites; Reduced UGT1A1 Activity and Impaired Bilirubin Glucuronidation
animal model: Gunn rat (homozygous jj, UGT1A1-null); Humanized UGT1 (hUGT1) mouse
|
| Pyrimidine 5-Nucleotidase Deficiency | modifier |
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.