STAT6

signal transducer and activator of transcription 6

6 disorders 3 untyped 2 no genetic record 1 somatic driver 12q13.3 gene with protein product

HGNC:11368 Monarch NCBI Gene 6778 ENSG00000166888 UniProt P42226 OMIM 601512

Aliases: D12S1644, IL-4-STAT.

In the knowledge base · computed from kb/ at build time

Disorders

Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.

Disorder	Relationship	Where the gene appears
Classic Hodgkin Lymphoma	somatic driver somatic	mechanism: Mutation-Driven JAK/STAT Activation
Atopic Dermatitis	untyped Associated	mechanism: Type 2 Immune Response
Solitary Fibrous Tumor	untyped somatic
STAT6 Gain-of-Function Disease	untyped autosomal dominant causal gain-of-function variant	mechanism: STAT6 gain-of-function variant
Asthma	no genetic record	mechanism: Type 2 Immune Response / Th2 Signaling
Hodgkin Lymphoma	no genetic record somatic	mechanism: Mutation-Driven JAK/STAT Activation (Classic HL) subtype: Classic HL

ClinGen gene–disease validity · snapshot 2026-10-03 · matched to entries by MONDO

An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.

ClinGen disease	MOI	Classification	dismech entry
hyper-IgE syndrome 6, autosomal dominant, with recurrent infections MONDO:0957807	AD	Strong 2024-10-08	STAT6 Gain-of-Function Disease untyped

Mechanism modules · computed from kb/

jak_stat_pathway_activation named in the module itself

Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.