Previous symbols: PARK1, PARK4. Aliases: NACP, PD1.
Relationship is the entry's genetic[].relationship_type. untyped means the entry has a genetic record for the gene but does not type it; its free-text association is shown instead.
| Disorder | Relationship | Where the gene appears |
|---|---|---|
| Dementia with Lewy Bodies | susceptibility | |
| Multiple System Atrophy | risk factor germline |
mechanism: Oligodendroglial Alpha-Synuclein Accumulation (GCIs)
|
| Parkinson's Disease | causative |
mechanism: Autophagy-Lysosome Pathway Dysfunction
subtype: PARK1; PARK4
discussion: (unnamed)
|
| Fabry disease | no genetic record |
mechanism: Autophagy impairment
|
| Manganism | no genetic record |
mechanism: Alpha-Synuclein Aggregation
|
An entry matches when ClinGen's MONDO disease is the entry's own disease term, a subtype term, or an exact-match mapping. An amber status marks an entry ClinGen supports the gene for (Definitive, Strong or Moderate) whose own record does not type it. A Limited, Disputed or Refuted tier on such an entry is not a gap.
| ClinGen disease | MOI | Classification | dismech entry |
|---|---|---|---|
| Parkinson disease MONDO:0005180 | AD | Definitive 2022-05-03 |
Parkinson's Disease
causative
|
Identity from HGNC (snapshot 2026-10-01). Page layers are described in the gene pages documentation.